- • Up to 20% off your first purchase
- • Bulk quantities available
- • Citation Reward application
Sample Application
- Animal health test
- In-vitro diagnostics
- Food & Feed Safety
- Environmental Safety
- New drug discovery
Supports
- Talk to our Expert:
[email protected] -
Talk to our sales:
[email protected]
Protocol Library Download
 |
 |
Anti-CST8/ CRES/ CTES5 functional antibody
Anti-CST8/ CRES/ CTES5 functional antibody for cell culture, ELISA & in-vivo assay
Go to CST8/CST8 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0837-Ab-1/ GM-Tg-hg-SE0837-Ab-2 | Anti-Human CST8 monoclonal antibody | Human |
| GM-Tg-rg-SE0837-Ab-1/ GM-Tg-rg-SE0837-Ab-2 | Anti-Rat CST8 monoclonal antibody | Rat |
| GM-Tg-mg-SE0837-Ab-1/ GM-Tg-mg-SE0837-Ab-2 | Anti-Mouse CST8 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0837-Ab-1/ GM-Tg-cynog-SE0837-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CST8 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0837-Ab-1/ GM-Tg-felg-SE0837-Ab-2 | Anti-Feline CST8 monoclonal antibody | Feline |
| GM-Tg-cang-SE0837-Ab-1/ GM-Tg-cang-SE0837-Ab-2 | Anti-Canine CST8 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0837-Ab-1/ GM-Tg-bovg-SE0837-Ab-2 | Anti-Bovine CST8 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0837-Ab-1/ GM-Tg-equg-SE0837-Ab-2 | Anti-Equine CST8 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0837-Ab-1/ GM-Tg-hg-SE0837-Ab-2; GM-Tg-rg-SE0837-Ab-1/ GM-Tg-rg-SE0837-Ab-2; GM-Tg-mg-SE0837-Ab-1/ GM-Tg-mg-SE0837-Ab-2; GM-Tg-cynog-SE0837-Ab-1/ GM-Tg-cynog-SE0837-Ab-2; GM-Tg-felg-SE0837-Ab-1/ GM-Tg-felg-SE0837-Ab-2; GM-Tg-cang-SE0837-Ab-1/ GM-Tg-cang-SE0837-Ab-2; GM-Tg-bovg-SE0837-Ab-1/ GM-Tg-bovg-SE0837-Ab-2; GM-Tg-equg-SE0837-Ab-1/ GM-Tg-equg-SE0837-Ab-2 |
| Products Name | Anti-CST8 monoclonal antibody |
| Format | mab |
| Target Name | CST8 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CST8 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0837-Ag-1 | Recombinant multi-species CST8/ CRES/ CTES5 protein |
Target information
| Target ID | GM-SE0837 |
| Target Name | CST8 |
| Gene ID | 10047,13012,29679,485735,101087829,617395,100630201 |
| Gene Symbol and Synonyms | CRES,Cst-rs1,CST8,CTES5 |
| Uniprot Accession | O60676,O88969 |
| Uniprot Entry Name | CST8_HUMAN,CST8_RAT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000125815 |
| Target Classification | N/A |
The target: CST8, gene name: CST8, also named as CRES, CTES5. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a protein similar to type 2 cystatins. The encoded protein exhibits highly tissue-specific expression in the reproductive tract, suggesting implicit roles in reproduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
Facebook
LinkedIn
Twitter
