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Anti-DSPP/ DFNA39/ DGI1 functional antibody
Anti-DSPP/ DFNA39/ DGI1 functional antibody for cell culture, ELISA & in-vivo assay
Go to DSPP/DSPP products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0895-Ab-1/ GM-Tg-hg-SE0895-Ab-2 | Anti-Human DSPP monoclonal antibody | Human |
| GM-Tg-rg-SE0895-Ab-1/ GM-Tg-rg-SE0895-Ab-2 | Anti-Rat DSPP monoclonal antibody | Rat |
| GM-Tg-mg-SE0895-Ab-1/ GM-Tg-mg-SE0895-Ab-2 | Anti-Mouse DSPP monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0895-Ab-1/ GM-Tg-cynog-SE0895-Ab-2 | Anti-Cynomolgus/ Rhesus macaque DSPP monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0895-Ab-1/ GM-Tg-felg-SE0895-Ab-2 | Anti-Feline DSPP monoclonal antibody | Feline |
| GM-Tg-cang-SE0895-Ab-1/ GM-Tg-cang-SE0895-Ab-2 | Anti-Canine DSPP monoclonal antibody | Canine |
| GM-Tg-bovg-SE0895-Ab-1/ GM-Tg-bovg-SE0895-Ab-2 | Anti-Bovine DSPP monoclonal antibody | Bovine |
| GM-Tg-equg-SE0895-Ab-1/ GM-Tg-equg-SE0895-Ab-2 | Anti-Equine DSPP monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0895-Ab-1/ GM-Tg-hg-SE0895-Ab-2; GM-Tg-rg-SE0895-Ab-1/ GM-Tg-rg-SE0895-Ab-2; GM-Tg-mg-SE0895-Ab-1/ GM-Tg-mg-SE0895-Ab-2; GM-Tg-cynog-SE0895-Ab-1/ GM-Tg-cynog-SE0895-Ab-2; GM-Tg-felg-SE0895-Ab-1/ GM-Tg-felg-SE0895-Ab-2; GM-Tg-cang-SE0895-Ab-1/ GM-Tg-cang-SE0895-Ab-2; GM-Tg-bovg-SE0895-Ab-1/ GM-Tg-bovg-SE0895-Ab-2; GM-Tg-equg-SE0895-Ab-1/ GM-Tg-equg-SE0895-Ab-2 |
| Products Name | Anti-DSPP monoclonal antibody |
| Format | mab |
| Target Name | DSPP |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-DSPP benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0895-Ag-1 | Recombinant multi-species DSPP/ DFNA39/ DGI1 protein |
Target information
| Target ID | GM-SE0895 |
| Target Name | DSPP |
| Gene ID | 1834,666279,25254,701581,100683557,101099202,100337125,102150816 |
| Gene Symbol and Synonyms | DFNA39,DGI1,Dmp2,DMP3,DPP,DSP,DSPP,RDSP2 |
| Uniprot Accession | Q9NZW4,Q62598 |
| Uniprot Entry Name | DSPP_HUMAN,DSPP_RAT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000152591 |
| Target Classification | N/A |
The target: DSPP, gene name: DSPP, also named as DFNA39, DGI1, DMP3, DPP, DSP. This gene encodes a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family of proteins. The encoded preproprotein is secreted by odontoblasts and proteolytically processed to generate two principal proteins of the dentin extracellular matrix of the tooth, dentin sialoprotein and dentin phosphoprotein. These two protein products may play distinct but related roles in dentin mineralization. Mutations in this gene are associated with dentinogenesis imperfecta and dentin dysplasia. This gene is present in a gene cluster on chromosome 4. Allelic differences due to repeat polymorphisms have been found for this gene. [provided by RefSeq, Jan 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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