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Anti-EDN3/ ET-3/ ET3 functional antibody
Anti-EDN3/ ET-3/ ET3 functional antibody for cell culture, ELISA & in-vivo assay
Go to EDN3/EDN3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0899-Ab-1/ GM-Tg-hg-SE0899-Ab-2 | Anti-Human EDN3 monoclonal antibody | Human |
| GM-Tg-rg-SE0899-Ab-1/ GM-Tg-rg-SE0899-Ab-2 | Anti-Rat EDN3 monoclonal antibody | Rat |
| GM-Tg-mg-SE0899-Ab-1/ GM-Tg-mg-SE0899-Ab-2 | Anti-Mouse EDN3 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0899-Ab-1/ GM-Tg-cynog-SE0899-Ab-2 | Anti-Cynomolgus/ Rhesus macaque EDN3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0899-Ab-1/ GM-Tg-felg-SE0899-Ab-2 | Anti-Feline EDN3 monoclonal antibody | Feline |
| GM-Tg-cang-SE0899-Ab-1/ GM-Tg-cang-SE0899-Ab-2 | Anti-Canine EDN3 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0899-Ab-1/ GM-Tg-bovg-SE0899-Ab-2 | Anti-Bovine EDN3 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0899-Ab-1/ GM-Tg-equg-SE0899-Ab-2 | Anti-Equine EDN3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0899-Ab-1/ GM-Tg-hg-SE0899-Ab-2; GM-Tg-rg-SE0899-Ab-1/ GM-Tg-rg-SE0899-Ab-2; GM-Tg-mg-SE0899-Ab-1/ GM-Tg-mg-SE0899-Ab-2; GM-Tg-cynog-SE0899-Ab-1/ GM-Tg-cynog-SE0899-Ab-2; GM-Tg-felg-SE0899-Ab-1/ GM-Tg-felg-SE0899-Ab-2; GM-Tg-cang-SE0899-Ab-1/ GM-Tg-cang-SE0899-Ab-2; GM-Tg-bovg-SE0899-Ab-1/ GM-Tg-bovg-SE0899-Ab-2; GM-Tg-equg-SE0899-Ab-1/ GM-Tg-equg-SE0899-Ab-2 |
| Products Name | Anti-EDN3 monoclonal antibody |
| Format | mab |
| Target Name | EDN3 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-EDN3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0899-Ag-1 | Recombinant multi-species EDN3/ ET-3/ ET3 protein |
| ORF Viral Vector | pGMLP002841 | human EDN3 Lentivirus plasmid |
| ORF Viral Vector | vGMLP002841 | human EDN3 Lentivirus particle |
| ORF Viral Vector | pGMLPm001040 | mouse Edn3 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001040 | mouse Edn3 Lentivirus particle |
Target information
| Target ID | GM-SE0899 |
| Target Name | EDN3 |
| Gene ID | 1908,13616,366270,693385,403406,111559745,513753,100034064 |
| Gene Symbol and Synonyms | EDN3,ET-3,ET3,HSCR4,ls,PPET3,preproET-3,RGD1564825,tmgc48,WS4B |
| Uniprot Accession | P14138,P13207,Q765Z4 |
| Uniprot Entry Name | EDN3_HUMAN,EDN3_RAT,EDN3_CANLF |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000124205 |
| Target Classification | N/A |
The target: EDN3, gene name: EDN3, also named as ET-3, ET3, HSCR4, PPET3, WS4B. The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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