Anti-ENAM/ ADAI/ AI1C functional antibody

Anti-ENAM/ ADAI/ AI1C functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to ENAM/ENAM products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE0904-Ab-1/ GM-Tg-hg-SE0904-Ab-2Anti-Human ENAM monoclonal antibodyHuman
GM-Tg-rg-SE0904-Ab-1/ GM-Tg-rg-SE0904-Ab-2Anti-Rat ENAM monoclonal antibodyRat
GM-Tg-mg-SE0904-Ab-1/ GM-Tg-mg-SE0904-Ab-2Anti-Mouse ENAM monoclonal antibodyMouse
GM-Tg-cynog-SE0904-Ab-1/ GM-Tg-cynog-SE0904-Ab-2Anti-Cynomolgus/ Rhesus macaque ENAM monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE0904-Ab-1/ GM-Tg-felg-SE0904-Ab-2Anti-Feline ENAM monoclonal antibodyFeline
GM-Tg-cang-SE0904-Ab-1/ GM-Tg-cang-SE0904-Ab-2Anti-Canine ENAM monoclonal antibodyCanine
GM-Tg-bovg-SE0904-Ab-1/ GM-Tg-bovg-SE0904-Ab-2Anti-Bovine ENAM monoclonal antibodyBovine
GM-Tg-equg-SE0904-Ab-1/ GM-Tg-equg-SE0904-Ab-2Anti-Equine ENAM monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE0904-Ab-1/ GM-Tg-hg-SE0904-Ab-2; GM-Tg-rg-SE0904-Ab-1/ GM-Tg-rg-SE0904-Ab-2;
GM-Tg-mg-SE0904-Ab-1/ GM-Tg-mg-SE0904-Ab-2; GM-Tg-cynog-SE0904-Ab-1/ GM-Tg-cynog-SE0904-Ab-2;
GM-Tg-felg-SE0904-Ab-1/ GM-Tg-felg-SE0904-Ab-2; GM-Tg-cang-SE0904-Ab-1/ GM-Tg-cang-SE0904-Ab-2;
GM-Tg-bovg-SE0904-Ab-1/ GM-Tg-bovg-SE0904-Ab-2; GM-Tg-equg-SE0904-Ab-1/ GM-Tg-equg-SE0904-Ab-2
Products NameAnti-ENAM monoclonal antibody
Formatmab
Target NameENAM
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-ENAM benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE0904-Ag-1Recombinant multi-species ENAM/ ADAI/ AI1C protein


    Target information

    Target IDGM-SE0904
    Target NameENAM
    Gene ID10117,13801,289525,706750,482186,101085542,527075,100049842
    Gene Symbol and Synonymsabte,ADAI,AI1C,AIH2,ENAM
    Uniprot AccessionQ9NRM1
    Uniprot Entry NameENAM_HUMAN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000132464
    Target ClassificationN/A

    The target: ENAM, gene name: ENAM, also named as ADAI, AI1C, AIH2. Dental enamel forms the outer cap of teeth and is the hardest substance found in vertebrates. This gene encodes the largest protein in the enamel matrix of developing teeth. The protein is involved in the mineralization and structural organization of enamel. Defects in this gene result in amelogenesis imperfect type 1C.[provided by RefSeq, Oct 2009].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.