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Anti-FCN3/ FCNH/ HAKA1 functional antibody
Anti-FCN3/ FCNH/ HAKA1 functional antibody for cell culture, ELISA & in-vivo assay
Go to FCN3/FCN3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0915-Ab-1/ GM-Tg-hg-SE0915-Ab-2 | Anti-Human FCN3 monoclonal antibody | Human |
| GM-Tg-rg-SE0915-Ab-1/ GM-Tg-rg-SE0915-Ab-2 | Anti-Rat FCN3 monoclonal antibody | Rat |
| GM-Tg-mg-SE0915-Ab-1/ GM-Tg-mg-SE0915-Ab-2 | Anti-Mouse FCN3 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0915-Ab-1/ GM-Tg-cynog-SE0915-Ab-2 | Anti-Cynomolgus/ Rhesus macaque FCN3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0915-Ab-1/ GM-Tg-felg-SE0915-Ab-2 | Anti-Feline FCN3 monoclonal antibody | Feline |
| GM-Tg-cang-SE0915-Ab-1/ GM-Tg-cang-SE0915-Ab-2 | Anti-Canine FCN3 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0915-Ab-1/ GM-Tg-bovg-SE0915-Ab-2 | Anti-Bovine FCN3 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0915-Ab-1/ GM-Tg-equg-SE0915-Ab-2 | Anti-Equine FCN3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0915-Ab-1/ GM-Tg-hg-SE0915-Ab-2; GM-Tg-rg-SE0915-Ab-1/ GM-Tg-rg-SE0915-Ab-2; GM-Tg-mg-SE0915-Ab-1/ GM-Tg-mg-SE0915-Ab-2; GM-Tg-cynog-SE0915-Ab-1/ GM-Tg-cynog-SE0915-Ab-2; GM-Tg-felg-SE0915-Ab-1/ GM-Tg-felg-SE0915-Ab-2; GM-Tg-cang-SE0915-Ab-1/ GM-Tg-cang-SE0915-Ab-2; GM-Tg-bovg-SE0915-Ab-1/ GM-Tg-bovg-SE0915-Ab-2; GM-Tg-equg-SE0915-Ab-1/ GM-Tg-equg-SE0915-Ab-2 |
| Products Name | Anti-FCN3 monoclonal antibody |
| Format | mab |
| Target Name | FCN3 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-FCN3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0915-Ag-1 | Recombinant multi-species FCN3/ FCNH/ HAKA1 protein |
| ORF Viral Vector | vGMLP004765 | human FCN3 Lentivirus particle |
| ORF Viral Vector | pGMLP004765 | human FCN3 Lentivirus plasmid |
Target information
| Target ID | GM-SE0915 |
| Target Name | FCN3 |
| Gene ID | 8547,720154,119870021,101082073,107131870,100070924 |
| Gene Symbol and Synonyms | FCN3,FCNH,HAKA1 |
| Uniprot Accession | O75636 |
| Uniprot Entry Name | FCN3_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000142748 |
| Target Classification | N/A |
The target: FCN3, gene name: FCN3, also named as FCNH, HAKA1. Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform, have been identified. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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