Anti-GPHA2/ A2/ GPA2 functional antibody

Anti-GPHA2/ A2/ GPA2 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to GPHA2/GPHA2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE0952-Ab-1/ GM-Tg-hg-SE0952-Ab-2Anti-Human GPHA2 monoclonal antibodyHuman
GM-Tg-rg-SE0952-Ab-1/ GM-Tg-rg-SE0952-Ab-2Anti-Rat GPHA2 monoclonal antibodyRat
GM-Tg-mg-SE0952-Ab-1/ GM-Tg-mg-SE0952-Ab-2Anti-Mouse GPHA2 monoclonal antibodyMouse
GM-Tg-cynog-SE0952-Ab-1/ GM-Tg-cynog-SE0952-Ab-2Anti-Cynomolgus/ Rhesus macaque GPHA2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE0952-Ab-1/ GM-Tg-felg-SE0952-Ab-2Anti-Feline GPHA2 monoclonal antibodyFeline
GM-Tg-cang-SE0952-Ab-1/ GM-Tg-cang-SE0952-Ab-2Anti-Canine GPHA2 monoclonal antibodyCanine
GM-Tg-bovg-SE0952-Ab-1/ GM-Tg-bovg-SE0952-Ab-2Anti-Bovine GPHA2 monoclonal antibodyBovine
GM-Tg-equg-SE0952-Ab-1/ GM-Tg-equg-SE0952-Ab-2Anti-Equine GPHA2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE0952-Ab-1/ GM-Tg-hg-SE0952-Ab-2; GM-Tg-rg-SE0952-Ab-1/ GM-Tg-rg-SE0952-Ab-2;
GM-Tg-mg-SE0952-Ab-1/ GM-Tg-mg-SE0952-Ab-2; GM-Tg-cynog-SE0952-Ab-1/ GM-Tg-cynog-SE0952-Ab-2;
GM-Tg-felg-SE0952-Ab-1/ GM-Tg-felg-SE0952-Ab-2; GM-Tg-cang-SE0952-Ab-1/ GM-Tg-cang-SE0952-Ab-2;
GM-Tg-bovg-SE0952-Ab-1/ GM-Tg-bovg-SE0952-Ab-2; GM-Tg-equg-SE0952-Ab-1/ GM-Tg-equg-SE0952-Ab-2
Products NameAnti-GPHA2 monoclonal antibody
Formatmab
Target NameGPHA2
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-GPHA2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE0952-Ag-1Recombinant multi-species GPHA2/ A2/ GPA2 protein


    Target information

    Target IDGM-SE0952
    Target NameGPHA2
    Gene ID170589,170458,171158,717261,100685596,101081412,617578,111775964
    Gene Symbol and SynonymsA2,C18H11orf85,GPA2,GPHA2,ZSIG51
    Uniprot AccessionQ96T91,Q925Q4
    Uniprot Entry NameGPHA2_HUMAN,GPHA2_RAT
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000149735
    Target ClassificationN/A

    The target: GPHA2, gene name: GPHA2, also named as A2, GPA2, ZSIG51. GPHA2 is a cystine knot-forming polypeptide and a subunit of the dimeric glycoprotein hormone family (Hsu et al., 2002 [PubMed 12089349]).[supplied by OMIM, Mar 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.