Anti-GPX6/ GPX5p/ GPXP3 functional antibody

Anti-GPX6/ GPX5p/ GPXP3 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to GPX6/GPX6 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE0957-Ab-1/ GM-Tg-hg-SE0957-Ab-2Anti-Human GPX6 monoclonal antibodyHuman
GM-Tg-rg-SE0957-Ab-1/ GM-Tg-rg-SE0957-Ab-2Anti-Rat GPX6 monoclonal antibodyRat
GM-Tg-mg-SE0957-Ab-1/ GM-Tg-mg-SE0957-Ab-2Anti-Mouse GPX6 monoclonal antibodyMouse
GM-Tg-cynog-SE0957-Ab-1/ GM-Tg-cynog-SE0957-Ab-2Anti-Cynomolgus/ Rhesus macaque GPX6 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE0957-Ab-1/ GM-Tg-felg-SE0957-Ab-2Anti-Feline GPX6 monoclonal antibodyFeline
GM-Tg-cang-SE0957-Ab-1/ GM-Tg-cang-SE0957-Ab-2Anti-Canine GPX6 monoclonal antibodyCanine
GM-Tg-bovg-SE0957-Ab-1/ GM-Tg-bovg-SE0957-Ab-2Anti-Bovine GPX6 monoclonal antibodyBovine
GM-Tg-equg-SE0957-Ab-1/ GM-Tg-equg-SE0957-Ab-2Anti-Equine GPX6 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE0957-Ab-1/ GM-Tg-hg-SE0957-Ab-2; GM-Tg-rg-SE0957-Ab-1/ GM-Tg-rg-SE0957-Ab-2;
GM-Tg-mg-SE0957-Ab-1/ GM-Tg-mg-SE0957-Ab-2; GM-Tg-cynog-SE0957-Ab-1/ GM-Tg-cynog-SE0957-Ab-2;
GM-Tg-felg-SE0957-Ab-1/ GM-Tg-felg-SE0957-Ab-2; GM-Tg-cang-SE0957-Ab-1/ GM-Tg-cang-SE0957-Ab-2;
GM-Tg-bovg-SE0957-Ab-1/ GM-Tg-bovg-SE0957-Ab-2; GM-Tg-equg-SE0957-Ab-1/ GM-Tg-equg-SE0957-Ab-2
Products NameAnti-GPX6 monoclonal antibody
Formatmab
Target NameGPX6
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-GPX6 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE0957-Ag-1Recombinant multi-species GPX6/ GPX5p/ GPXP3 protein


    Target information

    Target IDGM-SE0957
    Target NameGPX6
    Gene ID257202,75512,259233,100286832,488328,101087577,519280,100061078
    Gene Symbol and Synonyms1700020G18Rik,dJ1186N24,dJ1186N24.1,GPx-6,GPX5p,GPX6,GPXP3,GSHPx-6,OBPII,olfactory,Ry2d1
    Uniprot AccessionP59796,Q64625
    Uniprot Entry NameGPX6_HUMAN,GPX6_RAT
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000198704
    Target ClassificationN/A

    The target: GPX6, gene name: GPX6, also named as GPX5p, GPXP3, GPx-6, GSHPx-6, dJ1186N24, dJ1186N24.1. The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. Expression of this gene has been observed in embryos and olfactory epithelium; however, the exact function of this gene is not known. This isozyme is a selenoprotein in humans, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The orthologs of this gene in mouse and rat (and some other species) contain a cysteine (Cys) residue in place of the Sec residue, and their corresponding mRNAs lack SECIS element. [provided by RefSeq, Jul 2017].



    About Gmab

    GDU
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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.