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Anti-OXLA/ IL4I1/ FIG1 functional antibody
Anti-OXLA/ IL4I1/ FIG1 functional antibody for cell culture, ELISA & in-vivo assay
Go to IL4I1/IL4I1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1031-Ab-1/ GM-Tg-hg-SE1031-Ab-2 | Anti-Human IL4I1 monoclonal antibody | Human |
| GM-Tg-rg-SE1031-Ab-1/ GM-Tg-rg-SE1031-Ab-2 | Anti-Rat IL4I1 monoclonal antibody | Rat |
| GM-Tg-mg-SE1031-Ab-1/ GM-Tg-mg-SE1031-Ab-2 | Anti-Mouse IL4I1 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1031-Ab-1/ GM-Tg-cynog-SE1031-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IL4I1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1031-Ab-1/ GM-Tg-felg-SE1031-Ab-2 | Anti-Feline IL4I1 monoclonal antibody | Feline |
| GM-Tg-cang-SE1031-Ab-1/ GM-Tg-cang-SE1031-Ab-2 | Anti-Canine IL4I1 monoclonal antibody | Canine |
| GM-Tg-bovg-SE1031-Ab-1/ GM-Tg-bovg-SE1031-Ab-2 | Anti-Bovine IL4I1 monoclonal antibody | Bovine |
| GM-Tg-equg-SE1031-Ab-1/ GM-Tg-equg-SE1031-Ab-2 | Anti-Equine IL4I1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1031-Ab-1/ GM-Tg-hg-SE1031-Ab-2; GM-Tg-rg-SE1031-Ab-1/ GM-Tg-rg-SE1031-Ab-2; GM-Tg-mg-SE1031-Ab-1/ GM-Tg-mg-SE1031-Ab-2; GM-Tg-cynog-SE1031-Ab-1/ GM-Tg-cynog-SE1031-Ab-2; GM-Tg-felg-SE1031-Ab-1/ GM-Tg-felg-SE1031-Ab-2; GM-Tg-cang-SE1031-Ab-1/ GM-Tg-cang-SE1031-Ab-2; GM-Tg-bovg-SE1031-Ab-1/ GM-Tg-bovg-SE1031-Ab-2; GM-Tg-equg-SE1031-Ab-1/ GM-Tg-equg-SE1031-Ab-2 |
| Products Name | Anti-IL4I1 monoclonal antibody |
| Format | mab |
| Target Name | IL4I1 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-IL4I1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1031-Ag-1 | Recombinant multi-species OXLA/ IL4I1/ FIG1 protein |
| ORF Viral Vector | vGMLP002445 | 0 IL4I1 Lentivirus particle |
| ORF Viral Vector | pGMLP002445 | human IL4I1 Lentivirus plasmid |
Target information
| Target ID | GM-SE1031 |
| Target Name | IL4I1 |
| Gene ID | 259307,100360621,719114,484371,101100683,104968452,100147304 |
| Gene Symbol and Synonyms | FIG1,hIL4I1,IL4I1,LAAO,LAO |
| Uniprot Accession | Q96RQ9 |
| Uniprot Entry Name | OXLA_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000104951 |
| Target Classification | N/A |
The target: IL4I1, gene name: IL4I1, also named as FIG1, LAAO, LAO. This gene encodes a secreted L-amino acid oxidase protein which primarily catabolizes L-phenylalanine and, to a lesser extent, L-arginine. The expression of this gene is induced by the cytokine interleukin 4 in B cells. This gene is also expressed in macrophages and dendritic cells. This protein may play a role immune system escape as it is expressed in tumor-associated macrophages and suppresses T-cell responses. This protein also contains domains thought to be involved in the binding of flavin adenine dinucleotide (FAD) cofactor. Multiple transcript variants encoding different isoforms have been found for this gene. Some transcripts of this gene share a promoter and exons of the 5' UTR with the overlapping NUP62 gene. [provided by RefSeq, Jul 2020].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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