Anti-ITIH3/ H3P/ ITI-HC3 functional antibody

Anti-ITIH3/ H3P/ ITI-HC3 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to ITIH3/ITIH3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1040-Ab-1/ GM-Tg-hg-SE1040-Ab-2Anti-Human ITIH3 monoclonal antibodyHuman
GM-Tg-rg-SE1040-Ab-1/ GM-Tg-rg-SE1040-Ab-2Anti-Rat ITIH3 monoclonal antibodyRat
GM-Tg-mg-SE1040-Ab-1/ GM-Tg-mg-SE1040-Ab-2Anti-Mouse ITIH3 monoclonal antibodyMouse
GM-Tg-cynog-SE1040-Ab-1/ GM-Tg-cynog-SE1040-Ab-2Anti-Cynomolgus/ Rhesus macaque ITIH3 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1040-Ab-1/ GM-Tg-felg-SE1040-Ab-2Anti-Feline ITIH3 monoclonal antibodyFeline
GM-Tg-cang-SE1040-Ab-1/ GM-Tg-cang-SE1040-Ab-2Anti-Canine ITIH3 monoclonal antibodyCanine
GM-Tg-bovg-SE1040-Ab-1/ GM-Tg-bovg-SE1040-Ab-2Anti-Bovine ITIH3 monoclonal antibodyBovine
GM-Tg-equg-SE1040-Ab-1/ GM-Tg-equg-SE1040-Ab-2Anti-Equine ITIH3 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1040-Ab-1/ GM-Tg-hg-SE1040-Ab-2; GM-Tg-rg-SE1040-Ab-1/ GM-Tg-rg-SE1040-Ab-2;
GM-Tg-mg-SE1040-Ab-1/ GM-Tg-mg-SE1040-Ab-2; GM-Tg-cynog-SE1040-Ab-1/ GM-Tg-cynog-SE1040-Ab-2;
GM-Tg-felg-SE1040-Ab-1/ GM-Tg-felg-SE1040-Ab-2; GM-Tg-cang-SE1040-Ab-1/ GM-Tg-cang-SE1040-Ab-2;
GM-Tg-bovg-SE1040-Ab-1/ GM-Tg-bovg-SE1040-Ab-2; GM-Tg-equg-SE1040-Ab-1/ GM-Tg-equg-SE1040-Ab-2
Products NameAnti-ITIH3 monoclonal antibody
Formatmab
Target NameITIH3
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-ITIH3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1040-Ag-1Recombinant multi-species ITIH3/ H3P/ ITI-HC3 protein


    Target information

    Target IDGM-SE1040
    Target NameITIH3
    Gene ID3699,16426,50693,695200,491368,101086886,508355,100059937
    Gene Symbol and SynonymsH3P,Intin3,ITI-HC3,Itih-3,ITIH3,PAIHC3,SHAP
    Uniprot AccessionQ06033,Q63416,P56652
    Uniprot Entry NameITIH3_HUMAN,ITIH3_RAT,ITIH3_BOVIN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000162267
    Target ClassificationN/A

    The target: ITIH3, gene name: ITIH3, also named as H3P, ITI-HC3, SHAP. This gene encodes the heavy chain subunit of the pre-alpha-trypsin inhibitor complex. This complex may stabilize the extracellular matrix through its ability to bind hyaluronic acid. Polymorphisms of this gene may be associated with increased risk for schizophrenia and major depressive disorder. This gene is present in an inter-alpha-trypsin inhibitor family gene cluster on chromosome 3. [provided by RefSeq, Jul 2015].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.