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Anti-K1C10/ KRT10/ BCIE functional antibody
Anti-K1C10/ KRT10/ BCIE functional antibody for cell culture, ELISA & in-vivo assay
Go to KRT10/KRT10 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1053-Ab-1/ GM-Tg-hg-SE1053-Ab-2 | Anti-Human KRT10 monoclonal antibody | Human |
| GM-Tg-rg-SE1053-Ab-1/ GM-Tg-rg-SE1053-Ab-2 | Anti-Rat KRT10 monoclonal antibody | Rat |
| GM-Tg-mg-SE1053-Ab-1/ GM-Tg-mg-SE1053-Ab-2 | Anti-Mouse KRT10 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1053-Ab-1/ GM-Tg-cynog-SE1053-Ab-2 | Anti-Cynomolgus/ Rhesus macaque KRT10 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1053-Ab-1/ GM-Tg-felg-SE1053-Ab-2 | Anti-Feline KRT10 monoclonal antibody | Feline |
| GM-Tg-cang-SE1053-Ab-1/ GM-Tg-cang-SE1053-Ab-2 | Anti-Canine KRT10 monoclonal antibody | Canine |
| GM-Tg-bovg-SE1053-Ab-1/ GM-Tg-bovg-SE1053-Ab-2 | Anti-Bovine KRT10 monoclonal antibody | Bovine |
| GM-Tg-equg-SE1053-Ab-1/ GM-Tg-equg-SE1053-Ab-2 | Anti-Equine KRT10 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1053-Ab-1/ GM-Tg-hg-SE1053-Ab-2; GM-Tg-rg-SE1053-Ab-1/ GM-Tg-rg-SE1053-Ab-2; GM-Tg-mg-SE1053-Ab-1/ GM-Tg-mg-SE1053-Ab-2; GM-Tg-cynog-SE1053-Ab-1/ GM-Tg-cynog-SE1053-Ab-2; GM-Tg-felg-SE1053-Ab-1/ GM-Tg-felg-SE1053-Ab-2; GM-Tg-cang-SE1053-Ab-1/ GM-Tg-cang-SE1053-Ab-2; GM-Tg-bovg-SE1053-Ab-1/ GM-Tg-bovg-SE1053-Ab-2; GM-Tg-equg-SE1053-Ab-1/ GM-Tg-equg-SE1053-Ab-2 |
| Products Name | Anti-KRT10 monoclonal antibody |
| Format | mab |
| Target Name | KRT10 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-KRT10 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1053-Ag-1 | Recombinant multi-species K1C10/ KRT10/ BCIE protein |
| ORF Viral Vector | vGMLP001681 | human KRT10 Lentivirus particle |
| ORF Viral Vector | pGMLP001681 | human KRT10 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm004057 | mouse Krt10 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004057 | mouse Krt10 Lentivirus particle |
Target information
| Target ID | GM-SE1053 |
| Target Name | KRT10 |
| Gene ID | 3858,16661,450225,702153,281888 |
| Gene Symbol and Synonyms | BCIE,BIE,CK-10,CK10,D130054E02Rik,EHK,EHK2,IHL,K10,K1C1,Ka10,Ker10,Keratin-10,KPP,Krt-1.10,Krt1-10,KRT10 |
| Uniprot Accession | P13645,Q6IFW6,Q6EIZ0,P06394 |
| Uniprot Entry Name | K1C10_HUMAN,K1C10_RAT,K1C10_CANLF,K1C10_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | Malignant neoplasm of bladder |
| Gene Ensembl | ENSG00000186395 |
| Target Classification | N/A |
The target: KRT10, gene name: KRT10, also named as BCIE, BIE, CK10, EHK, K10, KPP. This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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