Anti-LOXL3/ LOXL functional antibody

Anti-LOXL3/ LOXL functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to LOXL3/LOXL3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1078-Ab-1/ GM-Tg-hg-SE1078-Ab-2Anti-Human LOXL3 monoclonal antibodyHuman
GM-Tg-rg-SE1078-Ab-1/ GM-Tg-rg-SE1078-Ab-2Anti-Rat LOXL3 monoclonal antibodyRat
GM-Tg-mg-SE1078-Ab-1/ GM-Tg-mg-SE1078-Ab-2Anti-Mouse LOXL3 monoclonal antibodyMouse
GM-Tg-cynog-SE1078-Ab-1/ GM-Tg-cynog-SE1078-Ab-2Anti-Cynomolgus/ Rhesus macaque LOXL3 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1078-Ab-1/ GM-Tg-felg-SE1078-Ab-2Anti-Feline LOXL3 monoclonal antibodyFeline
GM-Tg-cang-SE1078-Ab-1/ GM-Tg-cang-SE1078-Ab-2Anti-Canine LOXL3 monoclonal antibodyCanine
GM-Tg-bovg-SE1078-Ab-1/ GM-Tg-bovg-SE1078-Ab-2Anti-Bovine LOXL3 monoclonal antibodyBovine
GM-Tg-equg-SE1078-Ab-1/ GM-Tg-equg-SE1078-Ab-2Anti-Equine LOXL3 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1078-Ab-1/ GM-Tg-hg-SE1078-Ab-2; GM-Tg-rg-SE1078-Ab-1/ GM-Tg-rg-SE1078-Ab-2;
GM-Tg-mg-SE1078-Ab-1/ GM-Tg-mg-SE1078-Ab-2; GM-Tg-cynog-SE1078-Ab-1/ GM-Tg-cynog-SE1078-Ab-2;
GM-Tg-felg-SE1078-Ab-1/ GM-Tg-felg-SE1078-Ab-2; GM-Tg-cang-SE1078-Ab-1/ GM-Tg-cang-SE1078-Ab-2;
GM-Tg-bovg-SE1078-Ab-1/ GM-Tg-bovg-SE1078-Ab-2; GM-Tg-equg-SE1078-Ab-1/ GM-Tg-equg-SE1078-Ab-2
Products NameAnti-LOXL3 monoclonal antibody
Formatmab
Target NameLOXL3
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-LOXL3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1078-Ag-1Recombinant multi-species LOXL3/ LOXL protein


    Target information

    Target IDGM-SE1078
    Target NameLOXL3
    Gene ID84695,16950,312478,709834,483101,101087470,613599,100053584
    Gene Symbol and SynonymsLor2,LOXL,Loxl2,LOXL3,MYP28
    Uniprot AccessionP58215
    Uniprot Entry NameLOXL3_HUMAN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000115318
    Target ClassificationN/A

    The target: LOXL3, gene name: LOXL3, also named as LOXL. This gene encodes a lysyl oxidase, which likely functions as an amine oxidase and plays a role in the formation of crosslinks in collagens and elastin. Deletion of the related gene in mouse causes neonatal mortality with cleft palate, spine deformity, and defects in collagen organization. A mutation in this gene was found in a family with Stickler syndrome. [provided by RefSeq, Sep 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.