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Anti-HGFL/ MST1/ D3F15S2 functional antibody
Anti-HGFL/ MST1/ D3F15S2 functional antibody for cell culture, ELISA & in-vivo assay
Go to MST1/MST1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1104-Ab-1/ GM-Tg-hg-SE1104-Ab-2 | Anti-Human MST1 monoclonal antibody | Human |
| GM-Tg-rg-SE1104-Ab-1/ GM-Tg-rg-SE1104-Ab-2 | Anti-Rat MST1 monoclonal antibody | Rat |
| GM-Tg-mg-SE1104-Ab-1/ GM-Tg-mg-SE1104-Ab-2 | Anti-Mouse MST1 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1104-Ab-1/ GM-Tg-cynog-SE1104-Ab-2 | Anti-Cynomolgus/ Rhesus macaque MST1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1104-Ab-1/ GM-Tg-felg-SE1104-Ab-2 | Anti-Feline MST1 monoclonal antibody | Feline |
| GM-Tg-cang-SE1104-Ab-1/ GM-Tg-cang-SE1104-Ab-2 | Anti-Canine MST1 monoclonal antibody | Canine |
| GM-Tg-bovg-SE1104-Ab-1/ GM-Tg-bovg-SE1104-Ab-2 | Anti-Bovine MST1 monoclonal antibody | Bovine |
| GM-Tg-equg-SE1104-Ab-1/ GM-Tg-equg-SE1104-Ab-2 | Anti-Equine MST1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1104-Ab-1/ GM-Tg-hg-SE1104-Ab-2; GM-Tg-rg-SE1104-Ab-1/ GM-Tg-rg-SE1104-Ab-2; GM-Tg-mg-SE1104-Ab-1/ GM-Tg-mg-SE1104-Ab-2; GM-Tg-cynog-SE1104-Ab-1/ GM-Tg-cynog-SE1104-Ab-2; GM-Tg-felg-SE1104-Ab-1/ GM-Tg-felg-SE1104-Ab-2; GM-Tg-cang-SE1104-Ab-1/ GM-Tg-cang-SE1104-Ab-2; GM-Tg-bovg-SE1104-Ab-1/ GM-Tg-bovg-SE1104-Ab-2; GM-Tg-equg-SE1104-Ab-1/ GM-Tg-equg-SE1104-Ab-2 |
| Products Name | Anti-MST1 monoclonal antibody |
| Format | mab |
| Target Name | MST1 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-MST1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1104-Ag-1 | Recombinant multi-species HGFL/ MST1/ D3F15S2 protein |
| ORF Viral Vector | pGMLP001362 | human MST1 Lentivirus plasmid |
| ORF Viral Vector | vGMLP001362 | human MST1 Lentivirus particle |
| ORF Viral Vector | pGMAAV000263 | Norway rat Mst1 AAV plasmid |
| ORF Viral Vector | vGMAAV000263 | Norway rat Mst1 AAV particle |
Target information
| Target ID | GM-SE1104 |
| Target Name | MST1 |
| Gene ID | 4485,15235,24566,705811,484768,101086125,514667,102147382 |
| Gene Symbol and Synonyms | D3F15S2,D3F15S2h,D9H3F15S2,DNF15S2,DNF15S2h,E2F2,HGFL,MSP,MST1,NF15S2 |
| Uniprot Accession | P26927,Q24K22 |
| Uniprot Entry Name | HGFL_HUMAN,HGFL_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000173531 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: MST1, gene name: MST1, also named as D3F15S2, DNF15S2, HGFL, MSP, NF15S2. The protein encoded by this gene contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Despite the presence of the serine protease domain, the encoded protein may not have any proteolytic activity. The receptor for this protein is RON tyrosine kinase, which upon activation stimulates ciliary motility of ciliated epithelial lung cells. This protein is secreted and cleaved to form an alpha chain and a beta chain bridged by disulfide bonds. [provided by RefSeq, Jan 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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