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Anti-NAPSA/ KAP/ Kdap functional antibody
Anti-NAPSA/ KAP/ Kdap functional antibody for cell culture, ELISA & in-vivo assay
Go to NAPSA/NAPSA products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1119-Ab-1/ GM-Tg-hg-SE1119-Ab-2 | Anti-Human NAPSA monoclonal antibody | Human |
| GM-Tg-rg-SE1119-Ab-1/ GM-Tg-rg-SE1119-Ab-2 | Anti-Rat NAPSA monoclonal antibody | Rat |
| GM-Tg-mg-SE1119-Ab-1/ GM-Tg-mg-SE1119-Ab-2 | Anti-Mouse NAPSA monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1119-Ab-1/ GM-Tg-cynog-SE1119-Ab-2 | Anti-Cynomolgus/ Rhesus macaque NAPSA monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1119-Ab-1/ GM-Tg-felg-SE1119-Ab-2 | Anti-Feline NAPSA monoclonal antibody | Feline |
| GM-Tg-cang-SE1119-Ab-1/ GM-Tg-cang-SE1119-Ab-2 | Anti-Canine NAPSA monoclonal antibody | Canine |
| GM-Tg-bovg-SE1119-Ab-1/ GM-Tg-bovg-SE1119-Ab-2 | Anti-Bovine NAPSA monoclonal antibody | Bovine |
| GM-Tg-equg-SE1119-Ab-1/ GM-Tg-equg-SE1119-Ab-2 | Anti-Equine NAPSA monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1119-Ab-1/ GM-Tg-hg-SE1119-Ab-2; GM-Tg-rg-SE1119-Ab-1/ GM-Tg-rg-SE1119-Ab-2; GM-Tg-mg-SE1119-Ab-1/ GM-Tg-mg-SE1119-Ab-2; GM-Tg-cynog-SE1119-Ab-1/ GM-Tg-cynog-SE1119-Ab-2; GM-Tg-felg-SE1119-Ab-1/ GM-Tg-felg-SE1119-Ab-2; GM-Tg-cang-SE1119-Ab-1/ GM-Tg-cang-SE1119-Ab-2; GM-Tg-bovg-SE1119-Ab-1/ GM-Tg-bovg-SE1119-Ab-2; GM-Tg-equg-SE1119-Ab-1/ GM-Tg-equg-SE1119-Ab-2 |
| Products Name | Anti-NAPSA monoclonal antibody |
| Format | mab |
| Target Name | NAPSA |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-NAPSA benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1119-Ag-1 | Recombinant multi-species NAPSA/ KAP/ Kdap protein |
| ORF Viral Vector | pGMLPm003409 | mouse Napsa Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003409 | mouse Napsa Lentivirus particle |
Target information
| Target ID | GM-SE1119 |
| Target Name | NAPSA |
| Gene ID | 9476,16541,60575,476406,101088129,539259,100057514 |
| Gene Symbol and Synonyms | KAP,Kdap,NAP1,NAPA,NAPSA,pronapsin,SNAPA |
| Uniprot Accession | O96009 |
| Uniprot Entry Name | NAPSA_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000131400 |
| Target Classification | N/A |
The target: NAPSA, gene name: NAPSA, also named as KAP, Kdap, NAP1, NAPA, SNAPA. This gene encodes a member of the peptidase A1 family of aspartic proteases. The encoded preproprotein is proteolytically processed to generate an activation peptide and the mature protease. The activation peptides of aspartic proteinases function as inhibitors of the protease active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The encoded protease may play a role in the proteolytic processing of pulmonary surfactant protein B in the lung and may function in protein catabolism in the renal proximal tubules. This gene has been described as a marker for lung adenocarcinoma and renal cell carcinoma. [provided by RefSeq, Feb 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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