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Anti-NBL1/ D1S1733E/ DAN functional antibody
Anti-NBL1/ D1S1733E/ DAN functional antibody for cell culture, ELISA & in-vivo assay
Go to NBL1/NBL1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1121-Ab-1/ GM-Tg-hg-SE1121-Ab-2 | Anti-Human NBL1 monoclonal antibody | Human |
| GM-Tg-rg-SE1121-Ab-1/ GM-Tg-rg-SE1121-Ab-2 | Anti-Rat NBL1 monoclonal antibody | Rat |
| GM-Tg-mg-SE1121-Ab-1/ GM-Tg-mg-SE1121-Ab-2 | Anti-Mouse NBL1 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1121-Ab-1/ GM-Tg-cynog-SE1121-Ab-2 | Anti-Cynomolgus/ Rhesus macaque NBL1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1121-Ab-1/ GM-Tg-felg-SE1121-Ab-2 | Anti-Feline NBL1 monoclonal antibody | Feline |
| GM-Tg-cang-SE1121-Ab-1/ GM-Tg-cang-SE1121-Ab-2 | Anti-Canine NBL1 monoclonal antibody | Canine |
| GM-Tg-bovg-SE1121-Ab-1/ GM-Tg-bovg-SE1121-Ab-2 | Anti-Bovine NBL1 monoclonal antibody | Bovine |
| GM-Tg-equg-SE1121-Ab-1/ GM-Tg-equg-SE1121-Ab-2 | Anti-Equine NBL1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1121-Ab-1/ GM-Tg-hg-SE1121-Ab-2; GM-Tg-rg-SE1121-Ab-1/ GM-Tg-rg-SE1121-Ab-2; GM-Tg-mg-SE1121-Ab-1/ GM-Tg-mg-SE1121-Ab-2; GM-Tg-cynog-SE1121-Ab-1/ GM-Tg-cynog-SE1121-Ab-2; GM-Tg-felg-SE1121-Ab-1/ GM-Tg-felg-SE1121-Ab-2; GM-Tg-cang-SE1121-Ab-1/ GM-Tg-cang-SE1121-Ab-2; GM-Tg-bovg-SE1121-Ab-1/ GM-Tg-bovg-SE1121-Ab-2; GM-Tg-equg-SE1121-Ab-1/ GM-Tg-equg-SE1121-Ab-2 |
| Products Name | Anti-NBL1 monoclonal antibody |
| Format | mab |
| Target Name | NBL1 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-NBL1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1121-Ag-1 | Recombinant multi-species NBL1/ D1S1733E/ DAN protein |
Target information
| Target ID | GM-SE1121 |
| Target Name | NBL1 |
| Gene ID | 4681,17965,50594,703641,487403,101090533,535280,100071893 |
| Gene Symbol and Synonyms | D1S1733E,D4H1S1733E,DAN,Dana,DAND1,NB,NBL1,NO3 |
| Uniprot Accession | P41271,Q06880 |
| Uniprot Entry Name | NBL1_HUMAN,NBL1_RAT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000158747 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: NBL1, gene name: NBL1, also named as D1S1733E, DAN, DAND1, NB, NO3. This gene product is the founding member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of signaling molecules. These proteins are secreted, and act as BMP (bone morphogenetic protein) antagonists by binding to BMPs and preventing them from interacting with their receptors. They may thus play an important role during growth and development. Alternatively spliced transcript variants have been identified for this gene. Read-through transcripts between this locus and the upstream mitochondrial inner membrane organizing system 1 gene (GeneID 440574) have been observed. [provided by RefSeq, May 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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