Anti-NDP/ EVR2/ FEVR functional antibody

Anti-NDP/ EVR2/ FEVR functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to NDP/NDP products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1124-Ab-1/ GM-Tg-hg-SE1124-Ab-2Anti-Human NDP monoclonal antibodyHuman
GM-Tg-rg-SE1124-Ab-1/ GM-Tg-rg-SE1124-Ab-2Anti-Rat NDP monoclonal antibodyRat
GM-Tg-mg-SE1124-Ab-1/ GM-Tg-mg-SE1124-Ab-2Anti-Mouse NDP monoclonal antibodyMouse
GM-Tg-cynog-SE1124-Ab-1/ GM-Tg-cynog-SE1124-Ab-2Anti-Cynomolgus/ Rhesus macaque NDP monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1124-Ab-1/ GM-Tg-felg-SE1124-Ab-2Anti-Feline NDP monoclonal antibodyFeline
GM-Tg-cang-SE1124-Ab-1/ GM-Tg-cang-SE1124-Ab-2Anti-Canine NDP monoclonal antibodyCanine
GM-Tg-bovg-SE1124-Ab-1/ GM-Tg-bovg-SE1124-Ab-2Anti-Bovine NDP monoclonal antibodyBovine
GM-Tg-equg-SE1124-Ab-1/ GM-Tg-equg-SE1124-Ab-2Anti-Equine NDP monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1124-Ab-1/ GM-Tg-hg-SE1124-Ab-2; GM-Tg-rg-SE1124-Ab-1/ GM-Tg-rg-SE1124-Ab-2;
GM-Tg-mg-SE1124-Ab-1/ GM-Tg-mg-SE1124-Ab-2; GM-Tg-cynog-SE1124-Ab-1/ GM-Tg-cynog-SE1124-Ab-2;
GM-Tg-felg-SE1124-Ab-1/ GM-Tg-felg-SE1124-Ab-2; GM-Tg-cang-SE1124-Ab-1/ GM-Tg-cang-SE1124-Ab-2;
GM-Tg-bovg-SE1124-Ab-1/ GM-Tg-bovg-SE1124-Ab-2; GM-Tg-equg-SE1124-Ab-1/ GM-Tg-equg-SE1124-Ab-2
Products NameAnti-NDP monoclonal antibody
Formatmab
Target NameNDP
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-NDP benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1124-Ag-1Recombinant multi-species NDP/ EVR2/ FEVR protein


    Target information

    Target IDGM-SE1124
    Target NameNDP
    Gene ID4693,17986,363443,702203,612440,101092497,511596,100050800
    Gene Symbol and SynonymsEVR2,FEVR,ND,NDP,Ndph,RGD1563968
    Uniprot AccessionQ00604,Q2KI78
    Uniprot Entry NameNDP_HUMAN,NDP_BOVIN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000124479
    Target ClassificationN/A

    The target: NDP, gene name: NDP, also named as EVR2, FEVR, ND. This gene encodes a secreted protein with a cystein-knot motif that activates the Wnt/beta-catenin pathway. The protein forms disulfide-linked oligomers in the extracellular matrix. Mutations in this gene result in Norrie disease and X-linked exudative vitreoretinopathy. [provided by RefSeq, Feb 2009].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.