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Anti-NT2NC/ A1BG/ NOTCH2NLC functional antibody
Anti-NT2NC/ A1BG/ NOTCH2NLC functional antibody for cell culture, ELISA & in-vivo assay
Go to NOTCH2NLC/NOTCH2NLC, A1BG products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1131-Ab-1/ GM-Tg-hg-SE1131-Ab-2 | Anti-Human NOTCH2NLC/NOTCH2NLC, A1BG monoclonal antibody | Human |
| GM-Tg-rg-SE1131-Ab-1/ GM-Tg-rg-SE1131-Ab-2 | Anti-Rat NOTCH2NLC/NOTCH2NLC, A1BG monoclonal antibody | Rat |
| GM-Tg-mg-SE1131-Ab-1/ GM-Tg-mg-SE1131-Ab-2 | Anti-Mouse NOTCH2NLC/NOTCH2NLC, A1BG monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1131-Ab-1/ GM-Tg-cynog-SE1131-Ab-2 | Anti-Cynomolgus/ Rhesus macaque NOTCH2NLC/NOTCH2NLC, A1BG monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1131-Ab-1/ GM-Tg-felg-SE1131-Ab-2 | Anti-Feline NOTCH2NLC/NOTCH2NLC, A1BG monoclonal antibody | Feline |
| GM-Tg-cang-SE1131-Ab-1/ GM-Tg-cang-SE1131-Ab-2 | Anti-Canine NOTCH2NLC/NOTCH2NLC, A1BG monoclonal antibody | Canine |
| GM-Tg-bovg-SE1131-Ab-1/ GM-Tg-bovg-SE1131-Ab-2 | Anti-Bovine NOTCH2NLC/NOTCH2NLC, A1BG monoclonal antibody | Bovine |
| GM-Tg-equg-SE1131-Ab-1/ GM-Tg-equg-SE1131-Ab-2 | Anti-Equine NOTCH2NLC/NOTCH2NLC, A1BG monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1131-Ab-1/ GM-Tg-hg-SE1131-Ab-2; GM-Tg-rg-SE1131-Ab-1/ GM-Tg-rg-SE1131-Ab-2; GM-Tg-mg-SE1131-Ab-1/ GM-Tg-mg-SE1131-Ab-2; GM-Tg-cynog-SE1131-Ab-1/ GM-Tg-cynog-SE1131-Ab-2; GM-Tg-felg-SE1131-Ab-1/ GM-Tg-felg-SE1131-Ab-2; GM-Tg-cang-SE1131-Ab-1/ GM-Tg-cang-SE1131-Ab-2; GM-Tg-bovg-SE1131-Ab-1/ GM-Tg-bovg-SE1131-Ab-2; GM-Tg-equg-SE1131-Ab-1/ GM-Tg-equg-SE1131-Ab-2 |
| Products Name | Anti-NOTCH2NLC/NOTCH2NLC, A1BG monoclonal antibody |
| Format | mab |
| Target Name | NOTCH2NLC |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-NOTCH2NLC benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1131-Ag-1 | Recombinant multi-species NT2NC/ A1BG/ NOTCH2NLC protein |
Target information
| Target ID | GM-SE1131 |
| Target Name | NOTCH2NLC |
| Gene ID | 100996717,1 |
| Gene Symbol and Synonyms | A1B,A1BG,ABG,E™6,GAB,HYST2477,N2N,NIID,NOTCH2NL,NOTCH2NLA,NOTCH2NLC,OPDM3 |
| Uniprot Accession | P0DPK4, P04217 |
| Uniprot Entry Name | A1BG_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | Lung cancer, Type 1 diabetes mellitus, Diabetic Nephropathy, IgA glomerulonephritis, Nephrotic syndrome, Malignant neoplasm of bladder |
| Gene Ensembl | ENSG00000286219 |
| Target Classification | N/A |
The target: NOTCH2NLC, gene name: NOTCH2NLC, A1BG, also named as N2N, NOTCH2NL, NOTCH2NLA, A1B, ABG, GAB, HYST2477. Predicted to enable calcium ion binding activity. Involved in cerebral cortex development and positive regulation of Notch signaling pathway. Located in extracellular region. Implicated in essential tremor. [provided by Alliance of Genome Resources, Apr 2022], The protein encoded by this gene is a plasma glycoprotein of unknown function. The protein shows sequence similarity to the variable regions of some immunoglobulin supergene family member proteins. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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