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Anti-PROL1/ OPRPN/ BPLP functional antibody
Anti-PROL1/ OPRPN/ BPLP functional antibody for cell culture, ELISA & in-vivo assay
Go to OPRPN/OPRPN products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1157-Ab-1/ GM-Tg-hg-SE1157-Ab-2 | Anti-Human OPRPN monoclonal antibody | Human |
| GM-Tg-rg-SE1157-Ab-1/ GM-Tg-rg-SE1157-Ab-2 | Anti-Rat OPRPN monoclonal antibody | Rat |
| GM-Tg-mg-SE1157-Ab-1/ GM-Tg-mg-SE1157-Ab-2 | Anti-Mouse OPRPN monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1157-Ab-1/ GM-Tg-cynog-SE1157-Ab-2 | Anti-Cynomolgus/ Rhesus macaque OPRPN monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1157-Ab-1/ GM-Tg-felg-SE1157-Ab-2 | Anti-Feline OPRPN monoclonal antibody | Feline |
| GM-Tg-cang-SE1157-Ab-1/ GM-Tg-cang-SE1157-Ab-2 | Anti-Canine OPRPN monoclonal antibody | Canine |
| GM-Tg-bovg-SE1157-Ab-1/ GM-Tg-bovg-SE1157-Ab-2 | Anti-Bovine OPRPN monoclonal antibody | Bovine |
| GM-Tg-equg-SE1157-Ab-1/ GM-Tg-equg-SE1157-Ab-2 | Anti-Equine OPRPN monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1157-Ab-1/ GM-Tg-hg-SE1157-Ab-2; GM-Tg-rg-SE1157-Ab-1/ GM-Tg-rg-SE1157-Ab-2; GM-Tg-mg-SE1157-Ab-1/ GM-Tg-mg-SE1157-Ab-2; GM-Tg-cynog-SE1157-Ab-1/ GM-Tg-cynog-SE1157-Ab-2; GM-Tg-felg-SE1157-Ab-1/ GM-Tg-felg-SE1157-Ab-2; GM-Tg-cang-SE1157-Ab-1/ GM-Tg-cang-SE1157-Ab-2; GM-Tg-bovg-SE1157-Ab-1/ GM-Tg-bovg-SE1157-Ab-2; GM-Tg-equg-SE1157-Ab-1/ GM-Tg-equg-SE1157-Ab-2 |
| Products Name | Anti-OPRPN monoclonal antibody |
| Format | mab |
| Target Name | OPRPN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-OPRPN benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1157-Ag-1 | Recombinant multi-species PROL1/ OPRPN/ BPLP protein |
Target information
| Target ID | GM-SE1157 |
| Target Name | OPRPN |
| Gene ID | 58503,65182,100429306 |
| Gene Symbol and Synonyms | BPLP,Muc10,opiorphin,OPRPN,PRL1,PROL1,RSM-1 |
| Uniprot Accession | Q99935 |
| Uniprot Entry Name | PROL1_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000171199 |
| Target Classification | N/A |
The target: OPRPN, gene name: OPRPN, also named as BPLP, PRL1, PROL1, opiorphin. This gene encodes a member of the proline-rich protein family. The encoded protein has multiple proposed functions, including roles in pain suppression, penile erection, and protection of the eye surface. The QRFSR pentapeptide, known as opiorphin, is derived from the N-terminal of this protein. Opiorphin inhibits the enkephalin-inactivating peptidases neprilysin and aminopeptidase N, and this activity is thought to reduce sensitivity to painful stimuli by effecting enkephalin-related activation of opioid-dependent pathways. Opiorphin may also act as an anti-depressant. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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