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Anti-OTOG/ DFNB18B/ MLEMP functional antibody
Anti-OTOG/ DFNB18B/ MLEMP functional antibody for cell culture, ELISA & in-vivo assay
Go to OTOG/OTOG products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1161-Ab-1/ GM-Tg-hg-SE1161-Ab-2 | Anti-Human OTOG monoclonal antibody | Human |
| GM-Tg-rg-SE1161-Ab-1/ GM-Tg-rg-SE1161-Ab-2 | Anti-Rat OTOG monoclonal antibody | Rat |
| GM-Tg-mg-SE1161-Ab-1/ GM-Tg-mg-SE1161-Ab-2 | Anti-Mouse OTOG monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1161-Ab-1/ GM-Tg-cynog-SE1161-Ab-2 | Anti-Cynomolgus/ Rhesus macaque OTOG monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1161-Ab-1/ GM-Tg-felg-SE1161-Ab-2 | Anti-Feline OTOG monoclonal antibody | Feline |
| GM-Tg-cang-SE1161-Ab-1/ GM-Tg-cang-SE1161-Ab-2 | Anti-Canine OTOG monoclonal antibody | Canine |
| GM-Tg-bovg-SE1161-Ab-1/ GM-Tg-bovg-SE1161-Ab-2 | Anti-Bovine OTOG monoclonal antibody | Bovine |
| GM-Tg-equg-SE1161-Ab-1/ GM-Tg-equg-SE1161-Ab-2 | Anti-Equine OTOG monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1161-Ab-1/ GM-Tg-hg-SE1161-Ab-2; GM-Tg-rg-SE1161-Ab-1/ GM-Tg-rg-SE1161-Ab-2; GM-Tg-mg-SE1161-Ab-1/ GM-Tg-mg-SE1161-Ab-2; GM-Tg-cynog-SE1161-Ab-1/ GM-Tg-cynog-SE1161-Ab-2; GM-Tg-felg-SE1161-Ab-1/ GM-Tg-felg-SE1161-Ab-2; GM-Tg-cang-SE1161-Ab-1/ GM-Tg-cang-SE1161-Ab-2; GM-Tg-bovg-SE1161-Ab-1/ GM-Tg-bovg-SE1161-Ab-2; GM-Tg-equg-SE1161-Ab-1/ GM-Tg-equg-SE1161-Ab-2 |
| Products Name | Anti-OTOG monoclonal antibody |
| Format | mab |
| Target Name | OTOG |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-OTOG benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1161-Ag-1 | Recombinant multi-species OTOG/ DFNB18B/ MLEMP protein |
Target information
| Target ID | GM-SE1161 |
| Target Name | OTOG |
| Gene ID | 340990,18419,292918,100424357,485403,101096350,506301,100071797 |
| Gene Symbol and Synonyms | 4932420K09,DFNB18B,MLEMP,OTGN,OTOG,twt |
| Uniprot Accession | Q6ZRI0 |
| Uniprot Entry Name | OTOG_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000188162 |
| Target Classification | N/A |
The target: OTOG, gene name: OTOG, also named as DFNB18B, MLEMP, OTGN. The protein encoded by this gene is a component of the acellular membranes of the inner ear. Disruption of the orthologous mouse gene shows that it plays a role in auditory and vestibular functions. It is involved in fibrillar network organization, the anchoring of otoconial membranes and cupulae to the neuroepithelia, and likely in sound stimulation resistance. Mutations in this gene cause autosomal recessive nonsyndromic deafness, type 18B. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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