Anti-PPN/ PAPLN functional antibody

Anti-PPN/ PAPLN functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to PAPLN/PAPLN products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1168-Ab-1/ GM-Tg-hg-SE1168-Ab-2Anti-Human PAPLN monoclonal antibodyHuman
GM-Tg-rg-SE1168-Ab-1/ GM-Tg-rg-SE1168-Ab-2Anti-Rat PAPLN monoclonal antibodyRat
GM-Tg-mg-SE1168-Ab-1/ GM-Tg-mg-SE1168-Ab-2Anti-Mouse PAPLN monoclonal antibodyMouse
GM-Tg-cynog-SE1168-Ab-1/ GM-Tg-cynog-SE1168-Ab-2Anti-Cynomolgus/ Rhesus macaque PAPLN monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1168-Ab-1/ GM-Tg-felg-SE1168-Ab-2Anti-Feline PAPLN monoclonal antibodyFeline
GM-Tg-cang-SE1168-Ab-1/ GM-Tg-cang-SE1168-Ab-2Anti-Canine PAPLN monoclonal antibodyCanine
GM-Tg-bovg-SE1168-Ab-1/ GM-Tg-bovg-SE1168-Ab-2Anti-Bovine PAPLN monoclonal antibodyBovine
GM-Tg-equg-SE1168-Ab-1/ GM-Tg-equg-SE1168-Ab-2Anti-Equine PAPLN monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1168-Ab-1/ GM-Tg-hg-SE1168-Ab-2; GM-Tg-rg-SE1168-Ab-1/ GM-Tg-rg-SE1168-Ab-2;
GM-Tg-mg-SE1168-Ab-1/ GM-Tg-mg-SE1168-Ab-2; GM-Tg-cynog-SE1168-Ab-1/ GM-Tg-cynog-SE1168-Ab-2;
GM-Tg-felg-SE1168-Ab-1/ GM-Tg-felg-SE1168-Ab-2; GM-Tg-cang-SE1168-Ab-1/ GM-Tg-cang-SE1168-Ab-2;
GM-Tg-bovg-SE1168-Ab-1/ GM-Tg-bovg-SE1168-Ab-2; GM-Tg-equg-SE1168-Ab-1/ GM-Tg-equg-SE1168-Ab-2
Products NameAnti-PAPLN monoclonal antibody
Formatmab
Target NamePAPLN
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-PAPLN benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1168-Ag-1Recombinant multi-species PPN/ PAPLN protein


    Target information

    Target IDGM-SE1168
    Target NamePAPLN
    Gene ID89932,170721,314297,696394,490769,101091790,614084,100055755
    Gene Symbol and SynonymsE030033C16Rik,PAPLN,PPN
    Uniprot AccessionO95428
    Uniprot Entry NamePPN_HUMAN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000100767
    Target ClassificationN/A

    The target: PAPLN, gene name: PAPLN, also named as PPN. Predicted to enable metalloendopeptidase activity. Predicted to be involved in extracellular matrix organization. Predicted to be located in basement membrane. Predicted to be active in extracellular matrix. [provided by Alliance of Genome Resources, Apr 2022].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.