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Anti-PAPP1/ PAPPA/ ASBABP2 functional antibody
Anti-PAPP1/ PAPPA/ ASBABP2 functional antibody for cell culture, ELISA & in-vivo assay
Go to PAPPA/PAPPA products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1169-Ab-1/ GM-Tg-hg-SE1169-Ab-2 | Anti-Human PAPPA monoclonal antibody | Human |
| GM-Tg-rg-SE1169-Ab-1/ GM-Tg-rg-SE1169-Ab-2 | Anti-Rat PAPPA monoclonal antibody | Rat |
| GM-Tg-mg-SE1169-Ab-1/ GM-Tg-mg-SE1169-Ab-2 | Anti-Mouse PAPPA monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1169-Ab-1/ GM-Tg-cynog-SE1169-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PAPPA monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1169-Ab-1/ GM-Tg-felg-SE1169-Ab-2 | Anti-Feline PAPPA monoclonal antibody | Feline |
| GM-Tg-cang-SE1169-Ab-1/ GM-Tg-cang-SE1169-Ab-2 | Anti-Canine PAPPA monoclonal antibody | Canine |
| GM-Tg-bovg-SE1169-Ab-1/ GM-Tg-bovg-SE1169-Ab-2 | Anti-Bovine PAPPA monoclonal antibody | Bovine |
| GM-Tg-equg-SE1169-Ab-1/ GM-Tg-equg-SE1169-Ab-2 | Anti-Equine PAPPA monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1169-Ab-1/ GM-Tg-hg-SE1169-Ab-2; GM-Tg-rg-SE1169-Ab-1/ GM-Tg-rg-SE1169-Ab-2; GM-Tg-mg-SE1169-Ab-1/ GM-Tg-mg-SE1169-Ab-2; GM-Tg-cynog-SE1169-Ab-1/ GM-Tg-cynog-SE1169-Ab-2; GM-Tg-felg-SE1169-Ab-1/ GM-Tg-felg-SE1169-Ab-2; GM-Tg-cang-SE1169-Ab-1/ GM-Tg-cang-SE1169-Ab-2; GM-Tg-bovg-SE1169-Ab-1/ GM-Tg-bovg-SE1169-Ab-2; GM-Tg-equg-SE1169-Ab-1/ GM-Tg-equg-SE1169-Ab-2 |
| Products Name | Anti-PAPPA monoclonal antibody |
| Format | mab |
| Target Name | PAPPA |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PAPPA benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1169-Ag-1 | Recombinant multi-species PAPP1/ PAPPA/ ASBABP2 protein |
Target information
| Target ID | GM-SE1169 |
| Target Name | PAPPA |
| Gene ID | 5069,18491,313262,706783,481692,101089154,282647,100033920 |
| Gene Symbol and Synonyms | 8430414N03Rik,ASBABP2,DIPLA1,IGFBP-4ase,PAG1,PAPA,PAPP-A,PAPPA,PAPPA1 |
| Uniprot Accession | Q13219 |
| Uniprot Entry Name | PAPP1_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000182752 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: PAPPA, gene name: PAPPA, also named as ASBABP2, DIPLA1, IGFBP-4ase, PAPA, PAPP-A1, PAPPA. This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). Following IGFBP cleavage, insulin growth factors dissociate from IGFBPs and bind to IGF receptors, resulting in activation of the IGF pathway. The encoded protein plays a role in bone formation, inflammation, wound healing and female fertility. Enhanced expression of this protein is associated with diabetic nephropathy in human patients and this protein may promote tumor invasion and growth in various human cancers. [provided by RefSeq, Aug 2017].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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