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Anti-PGFRL/ PDGFRL/ PDGRL functional antibody
Anti-PGFRL/ PDGFRL/ PDGRL functional antibody for cell culture, ELISA & in-vivo assay
Go to PDGFRL/PDGFRL products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1177-Ab-1/ GM-Tg-hg-SE1177-Ab-2 | Anti-Human PDGFRL monoclonal antibody | Human |
| GM-Tg-rg-SE1177-Ab-1/ GM-Tg-rg-SE1177-Ab-2 | Anti-Rat PDGFRL monoclonal antibody | Rat |
| GM-Tg-mg-SE1177-Ab-1/ GM-Tg-mg-SE1177-Ab-2 | Anti-Mouse PDGFRL monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1177-Ab-1/ GM-Tg-cynog-SE1177-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PDGFRL monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1177-Ab-1/ GM-Tg-felg-SE1177-Ab-2 | Anti-Feline PDGFRL monoclonal antibody | Feline |
| GM-Tg-cang-SE1177-Ab-1/ GM-Tg-cang-SE1177-Ab-2 | Anti-Canine PDGFRL monoclonal antibody | Canine |
| GM-Tg-bovg-SE1177-Ab-1/ GM-Tg-bovg-SE1177-Ab-2 | Anti-Bovine PDGFRL monoclonal antibody | Bovine |
| GM-Tg-equg-SE1177-Ab-1/ GM-Tg-equg-SE1177-Ab-2 | Anti-Equine PDGFRL monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1177-Ab-1/ GM-Tg-hg-SE1177-Ab-2; GM-Tg-rg-SE1177-Ab-1/ GM-Tg-rg-SE1177-Ab-2; GM-Tg-mg-SE1177-Ab-1/ GM-Tg-mg-SE1177-Ab-2; GM-Tg-cynog-SE1177-Ab-1/ GM-Tg-cynog-SE1177-Ab-2; GM-Tg-felg-SE1177-Ab-1/ GM-Tg-felg-SE1177-Ab-2; GM-Tg-cang-SE1177-Ab-1/ GM-Tg-cang-SE1177-Ab-2; GM-Tg-bovg-SE1177-Ab-1/ GM-Tg-bovg-SE1177-Ab-2; GM-Tg-equg-SE1177-Ab-1/ GM-Tg-equg-SE1177-Ab-2 |
| Products Name | Anti-PDGFRL monoclonal antibody |
| Format | mab |
| Target Name | PDGFRL |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PDGFRL benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1177-Ag-1 | Recombinant multi-species PGFRL/ PDGFRL/ PDGRL protein |
| Cytokine | GM-Tg-g-SE1177-Ag-1 | platelet-derived growth factor receptor-like (PDGFRL) protein |
| ORF Viral Vector | pGMLPm004950 | mouse Pdgfrl Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004950 | mouse Pdgfrl Lentivirus particle |
Target information
| Target ID | GM-SE1177 |
| Target Name | PDGFRL |
| Gene ID | 5157,68797,290771,703117,607033,101083001,515017,100050306 |
| Gene Symbol and Synonyms | 1110039P19Rik,PDGFRL,PDGRL,PRLTS |
| Uniprot Accession | Q15198,Q5RJP7,Q5BIP2 |
| Uniprot Entry Name | PGFRL_HUMAN,PGFRL_RAT,PGFRL_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Cytokine Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000104213 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: PDGFRL, gene name: PDGFRL, also named as PDGRL, PRLTS. This gene encodes a protein with significant sequence similarity to the ligand binding domain of platelet-derived growth factor receptor beta. Mutations in this gene, or deletion of a chromosomal segment containing this gene, are associated with sporadic hepatocellular carcinomas, colorectal cancers, and non-small cell lung cancers. This suggests this gene product may function as a tumor suppressor. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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