Anti-PODN/ PCAN/ SLRR5A functional antibody

Anti-PODN/ PCAN/ SLRR5A functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to PODN/PODN products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1198-Ab-1/ GM-Tg-hg-SE1198-Ab-2Anti-Human PODN monoclonal antibodyHuman
GM-Tg-rg-SE1198-Ab-1/ GM-Tg-rg-SE1198-Ab-2Anti-Rat PODN monoclonal antibodyRat
GM-Tg-mg-SE1198-Ab-1/ GM-Tg-mg-SE1198-Ab-2Anti-Mouse PODN monoclonal antibodyMouse
GM-Tg-cynog-SE1198-Ab-1/ GM-Tg-cynog-SE1198-Ab-2Anti-Cynomolgus/ Rhesus macaque PODN monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1198-Ab-1/ GM-Tg-felg-SE1198-Ab-2Anti-Feline PODN monoclonal antibodyFeline
GM-Tg-cang-SE1198-Ab-1/ GM-Tg-cang-SE1198-Ab-2Anti-Canine PODN monoclonal antibodyCanine
GM-Tg-bovg-SE1198-Ab-1/ GM-Tg-bovg-SE1198-Ab-2Anti-Bovine PODN monoclonal antibodyBovine
GM-Tg-equg-SE1198-Ab-1/ GM-Tg-equg-SE1198-Ab-2Anti-Equine PODN monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1198-Ab-1/ GM-Tg-hg-SE1198-Ab-2; GM-Tg-rg-SE1198-Ab-1/ GM-Tg-rg-SE1198-Ab-2;
GM-Tg-mg-SE1198-Ab-1/ GM-Tg-mg-SE1198-Ab-2; GM-Tg-cynog-SE1198-Ab-1/ GM-Tg-cynog-SE1198-Ab-2;
GM-Tg-felg-SE1198-Ab-1/ GM-Tg-felg-SE1198-Ab-2; GM-Tg-cang-SE1198-Ab-1/ GM-Tg-cang-SE1198-Ab-2;
GM-Tg-bovg-SE1198-Ab-1/ GM-Tg-bovg-SE1198-Ab-2; GM-Tg-equg-SE1198-Ab-1/ GM-Tg-equg-SE1198-Ab-2
Products NameAnti-PODN monoclonal antibody
Formatmab
Target NamePODN
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-PODN benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1198-Ag-1Recombinant multi-species PODN/ PCAN/ SLRR5A protein


    Target information

    Target IDGM-SE1198
    Target NamePODN
    Gene ID127435,242608,102552895,715856,100687346,101092779,509606,100061224
    Gene Symbol and Synonyms9430070G18,LRRGT00160,PCAN,PODN,SLRR5A
    Uniprot AccessionQ7Z5L7
    Uniprot Entry NamePODN_HUMAN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000174348
    Target ClassificationN/A

    The target: PODN, gene name: PODN, also named as PCAN, SLRR5A. The protein encoded by this gene is a member of the small leucine-rich repeat protein family and contains an amino terminal CX3CXCX7C cysteine-rich cluster followed by a leucine-rich repeat domain. Studies suggest that this protein could function to inhibit smooth muscle cell proliferation and migration following arterial injury. [provided by RefSeq, Jul 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.