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Anti-PROK1/ EGVEGF/ PK1 functional antibody
Anti-PROK1/ EGVEGF/ PK1 functional antibody for cell culture, ELISA & in-vivo assay
Go to PROK1/PROK1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1206-Ab-1/ GM-Tg-hg-SE1206-Ab-2 | Anti-Human PROK1 monoclonal antibody | Human |
| GM-Tg-rg-SE1206-Ab-1/ GM-Tg-rg-SE1206-Ab-2 | Anti-Rat PROK1 monoclonal antibody | Rat |
| GM-Tg-mg-SE1206-Ab-1/ GM-Tg-mg-SE1206-Ab-2 | Anti-Mouse PROK1 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1206-Ab-1/ GM-Tg-cynog-SE1206-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PROK1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1206-Ab-1/ GM-Tg-felg-SE1206-Ab-2 | Anti-Feline PROK1 monoclonal antibody | Feline |
| GM-Tg-cang-SE1206-Ab-1/ GM-Tg-cang-SE1206-Ab-2 | Anti-Canine PROK1 monoclonal antibody | Canine |
| GM-Tg-bovg-SE1206-Ab-1/ GM-Tg-bovg-SE1206-Ab-2 | Anti-Bovine PROK1 monoclonal antibody | Bovine |
| GM-Tg-equg-SE1206-Ab-1/ GM-Tg-equg-SE1206-Ab-2 | Anti-Equine PROK1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1206-Ab-1/ GM-Tg-hg-SE1206-Ab-2; GM-Tg-rg-SE1206-Ab-1/ GM-Tg-rg-SE1206-Ab-2; GM-Tg-mg-SE1206-Ab-1/ GM-Tg-mg-SE1206-Ab-2; GM-Tg-cynog-SE1206-Ab-1/ GM-Tg-cynog-SE1206-Ab-2; GM-Tg-felg-SE1206-Ab-1/ GM-Tg-felg-SE1206-Ab-2; GM-Tg-cang-SE1206-Ab-1/ GM-Tg-cang-SE1206-Ab-2; GM-Tg-bovg-SE1206-Ab-1/ GM-Tg-bovg-SE1206-Ab-2; GM-Tg-equg-SE1206-Ab-1/ GM-Tg-equg-SE1206-Ab-2 |
| Products Name | Anti-PROK1 monoclonal antibody |
| Format | mab |
| Target Name | PROK1 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PROK1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1206-Ag-1 | Recombinant multi-species PROK1/ EGVEGF/ PK1 protein |
| ORF Viral Vector | pGMLP000925 | human PROK1 Lentivirus plasmid |
| ORF Viral Vector | vGMLP000925 | human PROK1 Lentivirus particle |
| ORF Viral Vector | pGMLPm000271 | mouse Prok1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000271 | mouse Prok1 Lentivirus particle |
Target information
| Target ID | GM-SE1206 |
| Target Name | PROK1 |
| Gene ID | 84432,246691,192205,701766,100856124,101083097,617599,100058664 |
| Gene Symbol and Synonyms | EG-VEGF,EGVEGF,PK1,PRK1,PROK1 |
| Uniprot Accession | P58294,Q8R414 |
| Uniprot Entry Name | PROK1_HUMAN,PROK1_RAT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000143125 |
| Target Classification | N/A |
The target: PROK1, gene name: PROK1, also named as EGVEGF, PK1, PRK1. The protein encoded by this gene induces proliferation, migration, and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. It has little or no effect on a variety of other endothelial and non-endothelial cell types. Its expression is restricted to the steroidogenic glands (ovary, testis, adrenal, and placenta), is induced by hypoxia, and often complementary to the expression of vascular endothelial growth factor (VEGF), suggesting that these molecules function in a coordinated manner. [provided by RefSeq, Sep 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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