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Anti-PROK2/ BV8/ HH4 functional antibody
Anti-PROK2/ BV8/ HH4 functional antibody for cell culture, ELISA & in-vivo assay
Go to PROK2/PROK2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1207-Ab-1/ GM-Tg-hg-SE1207-Ab-2 | Anti-Human PROK2 monoclonal antibody | Human |
| GM-Tg-rg-SE1207-Ab-1/ GM-Tg-rg-SE1207-Ab-2 | Anti-Rat PROK2 monoclonal antibody | Rat |
| GM-Tg-mg-SE1207-Ab-1/ GM-Tg-mg-SE1207-Ab-2 | Anti-Mouse PROK2 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1207-Ab-1/ GM-Tg-cynog-SE1207-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PROK2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1207-Ab-1/ GM-Tg-felg-SE1207-Ab-2 | Anti-Feline PROK2 monoclonal antibody | Feline |
| GM-Tg-cang-SE1207-Ab-1/ GM-Tg-cang-SE1207-Ab-2 | Anti-Canine PROK2 monoclonal antibody | Canine |
| GM-Tg-bovg-SE1207-Ab-1/ GM-Tg-bovg-SE1207-Ab-2 | Anti-Bovine PROK2 monoclonal antibody | Bovine |
| GM-Tg-equg-SE1207-Ab-1/ GM-Tg-equg-SE1207-Ab-2 | Anti-Equine PROK2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1207-Ab-1/ GM-Tg-hg-SE1207-Ab-2; GM-Tg-rg-SE1207-Ab-1/ GM-Tg-rg-SE1207-Ab-2; GM-Tg-mg-SE1207-Ab-1/ GM-Tg-mg-SE1207-Ab-2; GM-Tg-cynog-SE1207-Ab-1/ GM-Tg-cynog-SE1207-Ab-2; GM-Tg-felg-SE1207-Ab-1/ GM-Tg-felg-SE1207-Ab-2; GM-Tg-cang-SE1207-Ab-1/ GM-Tg-cang-SE1207-Ab-2; GM-Tg-bovg-SE1207-Ab-1/ GM-Tg-bovg-SE1207-Ab-2; GM-Tg-equg-SE1207-Ab-1/ GM-Tg-equg-SE1207-Ab-2 |
| Products Name | Anti-PROK2 monoclonal antibody |
| Format | mab |
| Target Name | PROK2 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PROK2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1207-Ag-1 | Recombinant multi-species PROK2/ BV8/ HH4 protein |
| ORF Viral Vector | pGMLP002169 | human PROK2 Lentivirus plasmid |
| ORF Viral Vector | vGMLP002169 | human PROK2 Lentivirus particle |
| ORF Viral Vector | pGMAAV000328 | house mouse Prok2 AAV plasmid |
| ORF Viral Vector | pGMLPm000163 | mouse Prok2 Lentivirus plasmid |
| ORF Viral Vector | vGMAAV000328 | house mouse Prok2 AAV particle |
| ORF Viral Vector | vGMLPm000163 | mouse Prok2 Lentivirus particle |
Target information
| Target ID | GM-SE1207 |
| Target Name | PROK2 |
| Gene ID | 60675,50501,192206,694450,119864655,102900844,387602,100629137 |
| Gene Symbol and Synonyms | BV8,HH4,KAL4,MIT1,PK2,Prok1,PROK2 |
| Uniprot Accession | Q9HC23,Q8R413,Q863H5 |
| Uniprot Entry Name | PROK2_HUMAN,PROK2_RAT,PROK2_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000163421 |
| Target Classification | N/A |
The target: PROK2, gene name: PROK2, also named as BV8, HH4, KAL4, MIT1, PK2. This gene encodes a protein expressed in the suprachiasmatic nucleus (SCN) circadian clock that may function as the output component of the circadian clock. The secreted form of the encoded protein may also serve as a chemoattractant for neuronal precursor cells in the olfactory bulb. Proteins from other vertebrates which are similar to this gene product were isolated based on homology to snake venom and secretions from frog skin, and have been shown to have diverse functions. Mutations in this gene are associated with Kallmann syndrome 4. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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