Anti-PSPN/ PSP functional antibody

Anti-PSPN/ PSP functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to PSPN/PSPN products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1228-Ab-1/ GM-Tg-hg-SE1228-Ab-2Anti-Human PSPN monoclonal antibodyHuman
GM-Tg-rg-SE1228-Ab-1/ GM-Tg-rg-SE1228-Ab-2Anti-Rat PSPN monoclonal antibodyRat
GM-Tg-mg-SE1228-Ab-1/ GM-Tg-mg-SE1228-Ab-2Anti-Mouse PSPN monoclonal antibodyMouse
GM-Tg-cynog-SE1228-Ab-1/ GM-Tg-cynog-SE1228-Ab-2Anti-Cynomolgus/ Rhesus macaque PSPN monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1228-Ab-1/ GM-Tg-felg-SE1228-Ab-2Anti-Feline PSPN monoclonal antibodyFeline
GM-Tg-cang-SE1228-Ab-1/ GM-Tg-cang-SE1228-Ab-2Anti-Canine PSPN monoclonal antibodyCanine
GM-Tg-bovg-SE1228-Ab-1/ GM-Tg-bovg-SE1228-Ab-2Anti-Bovine PSPN monoclonal antibodyBovine
GM-Tg-equg-SE1228-Ab-1/ GM-Tg-equg-SE1228-Ab-2Anti-Equine PSPN monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1228-Ab-1/ GM-Tg-hg-SE1228-Ab-2; GM-Tg-rg-SE1228-Ab-1/ GM-Tg-rg-SE1228-Ab-2;
GM-Tg-mg-SE1228-Ab-1/ GM-Tg-mg-SE1228-Ab-2; GM-Tg-cynog-SE1228-Ab-1/ GM-Tg-cynog-SE1228-Ab-2;
GM-Tg-felg-SE1228-Ab-1/ GM-Tg-felg-SE1228-Ab-2; GM-Tg-cang-SE1228-Ab-1/ GM-Tg-cang-SE1228-Ab-2;
GM-Tg-bovg-SE1228-Ab-1/ GM-Tg-bovg-SE1228-Ab-2; GM-Tg-equg-SE1228-Ab-1/ GM-Tg-equg-SE1228-Ab-2
Products NameAnti-PSPN monoclonal antibody
Formatmab
Target NamePSPN
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-PSPN benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1228-Ag-1Recombinant multi-species PSPN/ PSP protein
    CytokineGM-Tg-g-SE1228-Ag-1persephin (PSPN) protein


    Target information

    Target IDGM-SE1228
    Target NamePSPN
    Gene ID5623,19197,25525,699480,611734,101085955,518266,100065517
    Gene Symbol and SynonymsPSP,PSPN
    Uniprot AccessionO60542,O70301
    Uniprot Entry NamePSPN_HUMAN,PSPN_RAT
    Protein Sub-locationSecreted Protein/Potential Cytokines
    CategoryCytokine Target
    DiseaseN/A
    Gene EnsemblENSG00000125650
    Target ClassificationN/A

    The target: PSPN, gene name: PSPN, also named as PSP. This gene encodes a secreted ligand of the GDNF (glial cell line-derived neurotrophic factor) subfamily and TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein signals through the RET receptor tyrosine kinase and a GPI-linked coreceptor, and promotes survival of neuronal populations. This protein may play a role in cell death, and nervous system development and function. Elevated expression of this gene has been observed in oral squamous cell carcinoma. [provided by RefSeq, Aug 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.