Anti-RET3/ RBP3/ D10S64 functional antibody
Anti-RET3/ RBP3/ D10S64 functional antibody for cell culture, ELISA & in-vivo assay
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-SE1235-Ab-1/ GM-Tg-hg-SE1235-Ab-2 | Anti-Human RBP3 monoclonal antibody | Human |
GM-Tg-rg-SE1235-Ab-1/ GM-Tg-rg-SE1235-Ab-2 | Anti-Rat RBP3 monoclonal antibody | Rat |
GM-Tg-mg-SE1235-Ab-1/ GM-Tg-mg-SE1235-Ab-2 | Anti-Mouse RBP3 monoclonal antibody | Mouse |
GM-Tg-cynog-SE1235-Ab-1/ GM-Tg-cynog-SE1235-Ab-2 | Anti-Cynomolgus/ Rhesus macaque RBP3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-SE1235-Ab-1/ GM-Tg-felg-SE1235-Ab-2 | Anti-Feline RBP3 monoclonal antibody | Feline |
GM-Tg-cang-SE1235-Ab-1/ GM-Tg-cang-SE1235-Ab-2 | Anti-Canine RBP3 monoclonal antibody | Canine |
GM-Tg-bovg-SE1235-Ab-1/ GM-Tg-bovg-SE1235-Ab-2 | Anti-Bovine RBP3 monoclonal antibody | Bovine |
GM-Tg-equg-SE1235-Ab-1/ GM-Tg-equg-SE1235-Ab-2 | Anti-Equine RBP3 monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-SE1235-Ab-1/ GM-Tg-hg-SE1235-Ab-2; GM-Tg-rg-SE1235-Ab-1/ GM-Tg-rg-SE1235-Ab-2; GM-Tg-mg-SE1235-Ab-1/ GM-Tg-mg-SE1235-Ab-2; GM-Tg-cynog-SE1235-Ab-1/ GM-Tg-cynog-SE1235-Ab-2; GM-Tg-felg-SE1235-Ab-1/ GM-Tg-felg-SE1235-Ab-2; GM-Tg-cang-SE1235-Ab-1/ GM-Tg-cang-SE1235-Ab-2; GM-Tg-bovg-SE1235-Ab-1/ GM-Tg-bovg-SE1235-Ab-2; GM-Tg-equg-SE1235-Ab-1/ GM-Tg-equg-SE1235-Ab-2 |
Products Name | Anti-RBP3 monoclonal antibody |
Format | mab |
Target Name | RBP3 |
Protein Sub-location | Secreted Protein/Potential Cytokines |
Category of antibody | FACS/Biofunctional Antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-RBP3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | GM-Tg-g-SE1235-Ag-1 | Recombinant multi-species RET3/ RBP3/ D10S64 protein |
Target information
Target ID | GM-SE1235 |
Target Name | RBP3 |
Gene ID | 5949,19661,24711,711582,489084,101091050,281443,100063686 |
Gene Symbol and Synonyms | D10S64,D10S65,D10S66,IRBP,Rbp-3,RBP3,RBPI,RP66 |
Uniprot Accession | P10745,P12661 |
Uniprot Entry Name | RET3_HUMAN,RET3_BOVIN |
Protein Sub-location | Secreted Protein/Potential Cytokines |
Category | |
Disease | N/A |
Gene Ensembl | ENSG00000265203 |
Target Classification | N/A |
The target: RBP3, gene name: RBP3, also named as D10S64, D10S65, D10S66, IRBP, RBPI, RP66. Interphotoreceptor retinol-binding protein is a large glycoprotein known to bind retinoids and found primarily in the interphotoreceptor matrix of the retina between the retinal pigment epithelium and the photoreceptor cells. It is thought to transport retinoids between the retinal pigment epithelium and the photoreceptors, a critical role in the visual process.The human IRBP gene is approximately 9.5 kbp in length and consists of four exons separated by three introns. The introns are 1.6-1.9 kbp long. The gene is transcribed by photoreceptor and retinoblastoma cells into an approximately 4.3-kilobase mRNA that is translated and processed into a glycosylated protein of 135,000 Da. The amino acid sequence of human IRBP can be divided into four contiguous homology domains with 33-38% identity, suggesting a series of gene duplication events. In the gene, the boundaries of these domains are not defined by exon-intron junctions, as might have been expected. The first three homology domains and part of the fourth are all encoded by the first large exon, which is 3,180 base pairs long. The remainder of the fourth domain is encoded in the last three exons, which are 191, 143, and approximately 740 base pairs long, respectively. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.