Anti-RNAS8/ RNASE8/ RAE2 functional antibody

Anti-RNAS8/ RNASE8/ RAE2 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to RNASE8/RNASE8 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1249-Ab-1/ GM-Tg-hg-SE1249-Ab-2Anti-Human RNASE8 monoclonal antibodyHuman
GM-Tg-rg-SE1249-Ab-1/ GM-Tg-rg-SE1249-Ab-2Anti-Rat RNASE8 monoclonal antibodyRat
GM-Tg-mg-SE1249-Ab-1/ GM-Tg-mg-SE1249-Ab-2Anti-Mouse RNASE8 monoclonal antibodyMouse
GM-Tg-cynog-SE1249-Ab-1/ GM-Tg-cynog-SE1249-Ab-2Anti-Cynomolgus/ Rhesus macaque RNASE8 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1249-Ab-1/ GM-Tg-felg-SE1249-Ab-2Anti-Feline RNASE8 monoclonal antibodyFeline
GM-Tg-cang-SE1249-Ab-1/ GM-Tg-cang-SE1249-Ab-2Anti-Canine RNASE8 monoclonal antibodyCanine
GM-Tg-bovg-SE1249-Ab-1/ GM-Tg-bovg-SE1249-Ab-2Anti-Bovine RNASE8 monoclonal antibodyBovine
GM-Tg-equg-SE1249-Ab-1/ GM-Tg-equg-SE1249-Ab-2Anti-Equine RNASE8 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1249-Ab-1/ GM-Tg-hg-SE1249-Ab-2; GM-Tg-rg-SE1249-Ab-1/ GM-Tg-rg-SE1249-Ab-2;
GM-Tg-mg-SE1249-Ab-1/ GM-Tg-mg-SE1249-Ab-2; GM-Tg-cynog-SE1249-Ab-1/ GM-Tg-cynog-SE1249-Ab-2;
GM-Tg-felg-SE1249-Ab-1/ GM-Tg-felg-SE1249-Ab-2; GM-Tg-cang-SE1249-Ab-1/ GM-Tg-cang-SE1249-Ab-2;
GM-Tg-bovg-SE1249-Ab-1/ GM-Tg-bovg-SE1249-Ab-2; GM-Tg-equg-SE1249-Ab-1/ GM-Tg-equg-SE1249-Ab-2
Products NameAnti-RNASE8 monoclonal antibody
Formatmab
Target NameRNASE8
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-RNASE8 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1249-Ag-1Recombinant multi-species RNAS8/ RNASE8/ RAE2 protein


    Target information

    Target IDGM-SE1249
    Target NameRNASE8
    Gene ID122665,716333
    Gene Symbol and SynonymsRAE2,RNASE8
    Uniprot AccessionQ8TDE3
    Uniprot Entry NameRNAS8_HUMAN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000173431
    Target ClassificationN/A

    The target: RNASE8, gene name: RNASE8, also named as RAE2. The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein is expressed prominently in the placenta and exhibits antimicrobial activity against pathogenic bacteria and fungi. [provided by RefSeq, Oct 2014].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.