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Anti-RSPO2/ CRISTIN2/ HHRRD functional antibody
Anti-RSPO2/ CRISTIN2/ HHRRD functional antibody for cell culture, ELISA & in-vivo assay
Go to RSPO2/RSPO2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1254-Ab-1/ GM-Tg-hg-SE1254-Ab-2 | Anti-Human RSPO2 monoclonal antibody | Human |
| GM-Tg-rg-SE1254-Ab-1/ GM-Tg-rg-SE1254-Ab-2 | Anti-Rat RSPO2 monoclonal antibody | Rat |
| GM-Tg-mg-SE1254-Ab-1/ GM-Tg-mg-SE1254-Ab-2 | Anti-Mouse RSPO2 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1254-Ab-1/ GM-Tg-cynog-SE1254-Ab-2 | Anti-Cynomolgus/ Rhesus macaque RSPO2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1254-Ab-1/ GM-Tg-felg-SE1254-Ab-2 | Anti-Feline RSPO2 monoclonal antibody | Feline |
| GM-Tg-cang-SE1254-Ab-1/ GM-Tg-cang-SE1254-Ab-2 | Anti-Canine RSPO2 monoclonal antibody | Canine |
| GM-Tg-bovg-SE1254-Ab-1/ GM-Tg-bovg-SE1254-Ab-2 | Anti-Bovine RSPO2 monoclonal antibody | Bovine |
| GM-Tg-equg-SE1254-Ab-1/ GM-Tg-equg-SE1254-Ab-2 | Anti-Equine RSPO2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1254-Ab-1/ GM-Tg-hg-SE1254-Ab-2; GM-Tg-rg-SE1254-Ab-1/ GM-Tg-rg-SE1254-Ab-2; GM-Tg-mg-SE1254-Ab-1/ GM-Tg-mg-SE1254-Ab-2; GM-Tg-cynog-SE1254-Ab-1/ GM-Tg-cynog-SE1254-Ab-2; GM-Tg-felg-SE1254-Ab-1/ GM-Tg-felg-SE1254-Ab-2; GM-Tg-cang-SE1254-Ab-1/ GM-Tg-cang-SE1254-Ab-2; GM-Tg-bovg-SE1254-Ab-1/ GM-Tg-bovg-SE1254-Ab-2; GM-Tg-equg-SE1254-Ab-1/ GM-Tg-equg-SE1254-Ab-2 |
| Products Name | Anti-RSPO2 monoclonal antibody |
| Format | mab |
| Target Name | RSPO2 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-RSPO2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1254-Ag-1 | Recombinant multi-species RSPO2/ CRISTIN2/ HHRRD protein |
| ORF Viral Vector | pGMLV000011 | human RSPO2 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000011 | human RSPO2 Lentivirus particle |
| ORF Viral Vector | pGMLPm002435 | mouse Rspo2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002435 | mouse Rspo2 Lentivirus particle |
Target information
| Target ID | GM-SE1254 |
| Target Name | RSPO2 |
| Gene ID | 340419,239405,500863,697376,482004,101087380,536121,100056523 |
| Gene Symbol and Synonyms | 2610028F08Rik,CRISTIN2,D430027K22,ftls,HHRRD,RGD1562331,RSPO2,TETAMS2 |
| Uniprot Accession | Q6UXX9 |
| Uniprot Entry Name | RSPO2_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000147655 |
| Target Classification | N/A |
The target: RSPO2, gene name: RSPO2, also named as CRISTIN2, HHRRD, TETAMS2. This gene encodes a member of the R-spondin family of proteins. These proteins are secreted ligands of leucine-rich repeat containing G protein-coupled receptors that enhance Wnt signaling through the inhibition of ubiquitin E3 ligases. A chromosomal translocation including this locus that results in the formation of a gene fusion has been identified in multiple human cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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