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Anti-ISK5/ SPINK5/ LEKTI functional antibody
Anti-ISK5/ SPINK5/ LEKTI functional antibody for cell culture, ELISA & in-vivo assay
Go to SPINK5/SPINK5 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1312-Ab-1/ GM-Tg-hg-SE1312-Ab-2 | Anti-Human SPINK5 monoclonal antibody | Human |
| GM-Tg-rg-SE1312-Ab-1/ GM-Tg-rg-SE1312-Ab-2 | Anti-Rat SPINK5 monoclonal antibody | Rat |
| GM-Tg-mg-SE1312-Ab-1/ GM-Tg-mg-SE1312-Ab-2 | Anti-Mouse SPINK5 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1312-Ab-1/ GM-Tg-cynog-SE1312-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SPINK5 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1312-Ab-1/ GM-Tg-felg-SE1312-Ab-2 | Anti-Feline SPINK5 monoclonal antibody | Feline |
| GM-Tg-cang-SE1312-Ab-1/ GM-Tg-cang-SE1312-Ab-2 | Anti-Canine SPINK5 monoclonal antibody | Canine |
| GM-Tg-bovg-SE1312-Ab-1/ GM-Tg-bovg-SE1312-Ab-2 | Anti-Bovine SPINK5 monoclonal antibody | Bovine |
| GM-Tg-equg-SE1312-Ab-1/ GM-Tg-equg-SE1312-Ab-2 | Anti-Equine SPINK5 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1312-Ab-1/ GM-Tg-hg-SE1312-Ab-2; GM-Tg-rg-SE1312-Ab-1/ GM-Tg-rg-SE1312-Ab-2; GM-Tg-mg-SE1312-Ab-1/ GM-Tg-mg-SE1312-Ab-2; GM-Tg-cynog-SE1312-Ab-1/ GM-Tg-cynog-SE1312-Ab-2; GM-Tg-felg-SE1312-Ab-1/ GM-Tg-felg-SE1312-Ab-2; GM-Tg-cang-SE1312-Ab-1/ GM-Tg-cang-SE1312-Ab-2; GM-Tg-bovg-SE1312-Ab-1/ GM-Tg-bovg-SE1312-Ab-2; GM-Tg-equg-SE1312-Ab-1/ GM-Tg-equg-SE1312-Ab-2 |
| Products Name | Anti-SPINK5 monoclonal antibody |
| Format | mab |
| Target Name | SPINK5 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-SPINK5 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1312-Ag-1 | Recombinant multi-species ISK5/ SPINK5/ LEKTI protein |
Target information
| Target ID | GM-SE1312 |
| Target Name | SPINK5 |
| Gene ID | 11005,72432,361319,709424,478055,101086696,526637,100071873 |
| Gene Symbol and Synonyms | 2310065D10Rik,LEKT1,LEKTI,LETK1,LETKI,NETS,NS,SPINK5,VAKT1,VAKTI |
| Uniprot Accession | Q9NQ38 |
| Uniprot Entry Name | ISK5_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000133710 |
| Target Classification | N/A |
The target: SPINK5, gene name: SPINK5, also named as LEKTI, LETKI, NETS, NS, VAKTI. This gene encodes a multidomain serine protease inhibitor that contains 15 potential inhibitory domains. The encoded preproprotein is proteolytically processed to generate multiple protein products, which may exhibit unique activities and specificities. These proteins may play a role in skin and hair morphogenesis, as well as anti-inflammatory and antimicrobial protection of mucous epithelia. Mutations in this gene may result in Netherton syndrome, a disorder characterized by ichthyosis, defective cornification, and atopy. This gene is present in a gene cluster on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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