Anti-SPIT3/ SPINT3/ HKIB9 functional antibody

Anti-SPIT3/ SPINT3/ HKIB9 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to SPINT3/SPINT3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1315-Ab-1/ GM-Tg-hg-SE1315-Ab-2Anti-Human SPINT3 monoclonal antibodyHuman
GM-Tg-rg-SE1315-Ab-1/ GM-Tg-rg-SE1315-Ab-2Anti-Rat SPINT3 monoclonal antibodyRat
GM-Tg-mg-SE1315-Ab-1/ GM-Tg-mg-SE1315-Ab-2Anti-Mouse SPINT3 monoclonal antibodyMouse
GM-Tg-cynog-SE1315-Ab-1/ GM-Tg-cynog-SE1315-Ab-2Anti-Cynomolgus/ Rhesus macaque SPINT3 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1315-Ab-1/ GM-Tg-felg-SE1315-Ab-2Anti-Feline SPINT3 monoclonal antibodyFeline
GM-Tg-cang-SE1315-Ab-1/ GM-Tg-cang-SE1315-Ab-2Anti-Canine SPINT3 monoclonal antibodyCanine
GM-Tg-bovg-SE1315-Ab-1/ GM-Tg-bovg-SE1315-Ab-2Anti-Bovine SPINT3 monoclonal antibodyBovine
GM-Tg-equg-SE1315-Ab-1/ GM-Tg-equg-SE1315-Ab-2Anti-Equine SPINT3 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1315-Ab-1/ GM-Tg-hg-SE1315-Ab-2; GM-Tg-rg-SE1315-Ab-1/ GM-Tg-rg-SE1315-Ab-2;
GM-Tg-mg-SE1315-Ab-1/ GM-Tg-mg-SE1315-Ab-2; GM-Tg-cynog-SE1315-Ab-1/ GM-Tg-cynog-SE1315-Ab-2;
GM-Tg-felg-SE1315-Ab-1/ GM-Tg-felg-SE1315-Ab-2; GM-Tg-cang-SE1315-Ab-1/ GM-Tg-cang-SE1315-Ab-2;
GM-Tg-bovg-SE1315-Ab-1/ GM-Tg-bovg-SE1315-Ab-2; GM-Tg-equg-SE1315-Ab-1/ GM-Tg-equg-SE1315-Ab-2
Products NameAnti-SPINT3 monoclonal antibody
Formatmab
Target NameSPINT3
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-SPINT3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1315-Ag-1Recombinant multi-species SPIT3/ SPINT3/ HKIB9 protein


    Target information

    Target IDGM-SE1315
    Target NameSPINT3
    Gene ID10816,629747,685136,100423908,100296926,102149447
    Gene Symbol and SynonymsELP,Gm14315,HKIB9,SPINT3
    Uniprot AccessionP49223
    Uniprot Entry NameSPIT3_HUMAN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000101446
    Target ClassificationN/A

    The target: SPINT3, gene name: SPINT3, also named as HKIB9. Predicted to enable receptor antagonist activity and transforming growth factor beta binding activity. Predicted to be involved in negative regulation of transforming growth factor beta receptor signaling pathway. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.