Anti-SPXN/ SPX/ C12orf39 functional antibody

Anti-SPXN/ SPX/ C12orf39 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to SPX/SPX products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1320-Ab-1/ GM-Tg-hg-SE1320-Ab-2Anti-Human SPX monoclonal antibodyHuman
GM-Tg-rg-SE1320-Ab-1/ GM-Tg-rg-SE1320-Ab-2Anti-Rat SPX monoclonal antibodyRat
GM-Tg-mg-SE1320-Ab-1/ GM-Tg-mg-SE1320-Ab-2Anti-Mouse SPX monoclonal antibodyMouse
GM-Tg-cynog-SE1320-Ab-1/ GM-Tg-cynog-SE1320-Ab-2Anti-Cynomolgus/ Rhesus macaque SPX monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1320-Ab-1/ GM-Tg-felg-SE1320-Ab-2Anti-Feline SPX monoclonal antibodyFeline
GM-Tg-cang-SE1320-Ab-1/ GM-Tg-cang-SE1320-Ab-2Anti-Canine SPX monoclonal antibodyCanine
GM-Tg-bovg-SE1320-Ab-1/ GM-Tg-bovg-SE1320-Ab-2Anti-Bovine SPX monoclonal antibodyBovine
GM-Tg-equg-SE1320-Ab-1/ GM-Tg-equg-SE1320-Ab-2Anti-Equine SPX monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1320-Ab-1/ GM-Tg-hg-SE1320-Ab-2; GM-Tg-rg-SE1320-Ab-1/ GM-Tg-rg-SE1320-Ab-2;
GM-Tg-mg-SE1320-Ab-1/ GM-Tg-mg-SE1320-Ab-2; GM-Tg-cynog-SE1320-Ab-1/ GM-Tg-cynog-SE1320-Ab-2;
GM-Tg-felg-SE1320-Ab-1/ GM-Tg-felg-SE1320-Ab-2; GM-Tg-cang-SE1320-Ab-1/ GM-Tg-cang-SE1320-Ab-2;
GM-Tg-bovg-SE1320-Ab-1/ GM-Tg-bovg-SE1320-Ab-2; GM-Tg-equg-SE1320-Ab-1/ GM-Tg-equg-SE1320-Ab-2
Products NameAnti-SPX monoclonal antibody
Formatmab
Target NameSPX
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-SPX benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1320-Ag-1Recombinant multi-species SPXN/ SPX/ C12orf39 protein


    Target information

    Target IDGM-SE1320
    Target NameSPX
    Gene ID80763,319552,691138,706042,102151474,101096156,509493,100147193
    Gene Symbol and SynonymsB230216G23Rik,C12orf39,C27H12orf39,C5H12orf39,C6H12orf39,CB4H12orf39,Npq,SPX,SPX1
    Uniprot AccessionQ9BT56,M0R8L2,Q0VC44
    Uniprot Entry NameSPXN_HUMAN,SPXN_RAT,SPXN_BOVIN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000134548
    Target ClassificationN/A

    The target: SPX, gene name: SPX, also named as C12orf39. The protein encoded by this gene is a hormone involved in modulation of cardiovascular and renal function. It has also been shown in rats to cause weight loss. Several transcript variants have been found for this gene. [provided by RefSeq, Feb 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.