Anti-TKN4/ TAC4/ EK functional antibody

Anti-TKN4/ TAC4/ EK functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to TAC4/TAC4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1329-Ab-1/ GM-Tg-hg-SE1329-Ab-2Anti-Human TAC4 monoclonal antibodyHuman
GM-Tg-rg-SE1329-Ab-1/ GM-Tg-rg-SE1329-Ab-2Anti-Rat TAC4 monoclonal antibodyRat
GM-Tg-mg-SE1329-Ab-1/ GM-Tg-mg-SE1329-Ab-2Anti-Mouse TAC4 monoclonal antibodyMouse
GM-Tg-cynog-SE1329-Ab-1/ GM-Tg-cynog-SE1329-Ab-2Anti-Cynomolgus/ Rhesus macaque TAC4 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1329-Ab-1/ GM-Tg-felg-SE1329-Ab-2Anti-Feline TAC4 monoclonal antibodyFeline
GM-Tg-cang-SE1329-Ab-1/ GM-Tg-cang-SE1329-Ab-2Anti-Canine TAC4 monoclonal antibodyCanine
GM-Tg-bovg-SE1329-Ab-1/ GM-Tg-bovg-SE1329-Ab-2Anti-Bovine TAC4 monoclonal antibodyBovine
GM-Tg-equg-SE1329-Ab-1/ GM-Tg-equg-SE1329-Ab-2Anti-Equine TAC4 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1329-Ab-1/ GM-Tg-hg-SE1329-Ab-2; GM-Tg-rg-SE1329-Ab-1/ GM-Tg-rg-SE1329-Ab-2;
GM-Tg-mg-SE1329-Ab-1/ GM-Tg-mg-SE1329-Ab-2; GM-Tg-cynog-SE1329-Ab-1/ GM-Tg-cynog-SE1329-Ab-2;
GM-Tg-felg-SE1329-Ab-1/ GM-Tg-felg-SE1329-Ab-2; GM-Tg-cang-SE1329-Ab-1/ GM-Tg-cang-SE1329-Ab-2;
GM-Tg-bovg-SE1329-Ab-1/ GM-Tg-bovg-SE1329-Ab-2; GM-Tg-equg-SE1329-Ab-1/ GM-Tg-equg-SE1329-Ab-2
Products NameAnti-TAC4 monoclonal antibody
Formatmab
Target NameTAC4
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-TAC4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1329-Ag-1Recombinant multi-species TKN4/ TAC4/ EK protein


    Target information

    Target IDGM-SE1329
    Target NameTAC4
    Gene ID255061,93670,282829,100426023,100688531,102899881,101902680,100630394
    Gene Symbol and SynonymsEK,HK-1,HK1,PPT-C,TAC4
    Uniprot AccessionQ86UU9,Q8CH01
    Uniprot Entry NameTKN4_HUMAN,TKN4_RAT
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000176358
    Target ClassificationN/A

    The target: TAC4, gene name: TAC4, also named as EK, HK-1, HK1, PPT-C. This gene is a member of the tachykinin family of neurotransmitter-encoding genes. Tachykinin proteins are cleaved into small, secreted peptides that activate members of a family of receptor proteins. The products of this gene preferentially activate tachykinin receptor 1, and are thought to regulate peripheral endocrine and paracrine functions including blood pressure, the immune system, and endocrine gland secretion. The products of this gene lack a dibasic cleavage site found in other tachykinin proteins. Consequently, the nature of the cleavage products generated in vivo remains to be determined. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.