Anti-TSP4/ THBS4/ TSP-4 functional antibody

Anti-TSP4/ THBS4/ TSP-4 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to THBS4/THBS4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1336-Ab-1/ GM-Tg-hg-SE1336-Ab-2Anti-Human THBS4 monoclonal antibodyHuman
GM-Tg-rg-SE1336-Ab-1/ GM-Tg-rg-SE1336-Ab-2Anti-Rat THBS4 monoclonal antibodyRat
GM-Tg-mg-SE1336-Ab-1/ GM-Tg-mg-SE1336-Ab-2Anti-Mouse THBS4 monoclonal antibodyMouse
GM-Tg-cynog-SE1336-Ab-1/ GM-Tg-cynog-SE1336-Ab-2Anti-Cynomolgus/ Rhesus macaque THBS4 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1336-Ab-1/ GM-Tg-felg-SE1336-Ab-2Anti-Feline THBS4 monoclonal antibodyFeline
GM-Tg-cang-SE1336-Ab-1/ GM-Tg-cang-SE1336-Ab-2Anti-Canine THBS4 monoclonal antibodyCanine
GM-Tg-bovg-SE1336-Ab-1/ GM-Tg-bovg-SE1336-Ab-2Anti-Bovine THBS4 monoclonal antibodyBovine
GM-Tg-equg-SE1336-Ab-1/ GM-Tg-equg-SE1336-Ab-2Anti-Equine THBS4 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1336-Ab-1/ GM-Tg-hg-SE1336-Ab-2; GM-Tg-rg-SE1336-Ab-1/ GM-Tg-rg-SE1336-Ab-2;
GM-Tg-mg-SE1336-Ab-1/ GM-Tg-mg-SE1336-Ab-2; GM-Tg-cynog-SE1336-Ab-1/ GM-Tg-cynog-SE1336-Ab-2;
GM-Tg-felg-SE1336-Ab-1/ GM-Tg-felg-SE1336-Ab-2; GM-Tg-cang-SE1336-Ab-1/ GM-Tg-cang-SE1336-Ab-2;
GM-Tg-bovg-SE1336-Ab-1/ GM-Tg-bovg-SE1336-Ab-2; GM-Tg-equg-SE1336-Ab-1/ GM-Tg-equg-SE1336-Ab-2
Products NameAnti-THBS4 monoclonal antibody
Formatmab
Target NameTHBS4
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-THBS4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1336-Ag-1Recombinant multi-species TSP4/ THBS4/ TSP-4 protein
    ORF Viral VectorpGMLPm004116mouse Thbs4 Lentivirus plasmid
    ORF Viral VectorvGMLPm004116mouse Thbs4 Lentivirus particle


    Target information

    Target IDGM-SE1336
    Target NameTHBS4
    Gene ID7060,21828,29220,574276,488930,101087199,541281,100073261
    Gene Symbol and SynonymsTHBS4,TSP-4,TSP4
    Uniprot AccessionP35443,P49744,Q3SWW8
    Uniprot Entry NameTSP4_HUMAN,TSP4_RAT,TSP4_BOVIN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000113296
    Target ClassificationN/A

    The target: THBS4, gene name: THBS4, also named as TSP-4, TSP4. The protein encoded by this gene belongs to the thrombospondin protein family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentamer and can bind to heparin and calcium. It is involved in local signaling in the developing and adult nervous system, and it contributes to spinal sensitization and neuropathic pain states. This gene is activated during the stromal response to invasive breast cancer. It may also play a role in inflammatory responses in Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.