Anti-THNS2/ THNSL2/ SOFAT functional antibody

Anti-THNS2/ THNSL2/ SOFAT functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to THNSL2/THNSL2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1337-Ab-1/ GM-Tg-hg-SE1337-Ab-2Anti-Human THNSL2 monoclonal antibodyHuman
GM-Tg-rg-SE1337-Ab-1/ GM-Tg-rg-SE1337-Ab-2Anti-Rat THNSL2 monoclonal antibodyRat
GM-Tg-mg-SE1337-Ab-1/ GM-Tg-mg-SE1337-Ab-2Anti-Mouse THNSL2 monoclonal antibodyMouse
GM-Tg-cynog-SE1337-Ab-1/ GM-Tg-cynog-SE1337-Ab-2Anti-Cynomolgus/ Rhesus macaque THNSL2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1337-Ab-1/ GM-Tg-felg-SE1337-Ab-2Anti-Feline THNSL2 monoclonal antibodyFeline
GM-Tg-cang-SE1337-Ab-1/ GM-Tg-cang-SE1337-Ab-2Anti-Canine THNSL2 monoclonal antibodyCanine
GM-Tg-bovg-SE1337-Ab-1/ GM-Tg-bovg-SE1337-Ab-2Anti-Bovine THNSL2 monoclonal antibodyBovine
GM-Tg-equg-SE1337-Ab-1/ GM-Tg-equg-SE1337-Ab-2Anti-Equine THNSL2 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1337-Ab-1/ GM-Tg-hg-SE1337-Ab-2; GM-Tg-rg-SE1337-Ab-1/ GM-Tg-rg-SE1337-Ab-2;
GM-Tg-mg-SE1337-Ab-1/ GM-Tg-mg-SE1337-Ab-2; GM-Tg-cynog-SE1337-Ab-1/ GM-Tg-cynog-SE1337-Ab-2;
GM-Tg-felg-SE1337-Ab-1/ GM-Tg-felg-SE1337-Ab-2; GM-Tg-cang-SE1337-Ab-1/ GM-Tg-cang-SE1337-Ab-2;
GM-Tg-bovg-SE1337-Ab-1/ GM-Tg-bovg-SE1337-Ab-2; GM-Tg-equg-SE1337-Ab-1/ GM-Tg-equg-SE1337-Ab-2
Products NameAnti-THNSL2 monoclonal antibody
Formatmab
Target NameTHNSL2
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-THNSL2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1337-Ag-1Recombinant multi-species THNS2/ THNSL2/ SOFAT protein


    Target information

    Target IDGM-SE1337
    Target NameTHNSL2
    Gene ID55258,232078,297332,699203,475757,101095735,541205,100066561
    Gene Symbol and SynonymsRGD1309144,SOFAT,THNSL2,THS2,TSH2
    Uniprot AccessionQ86YJ6,Q5M7T9
    Uniprot Entry NameTHNS2_HUMAN,THNS2_RAT
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000144115
    Target ClassificationN/A

    The target: THNSL2, gene name: THNSL2, also named as SOFAT, THS2, TSH2. This gene encodes a threonine synthase-like protein. A similar enzyme in mouse can catalyze the degradation of O-phospho-homoserine to a-ketobutyrate, phosphate, and ammonia. This protein also has phospho-lyase activity on both gamma and beta phosphorylated substrates. In mouse an alternatively spliced form of this protein has been shown to act as a cytokine and can induce the production of the inflammatory cytokine IL6 in osteoblasts. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.