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Anti-TIMP2/ CSC-21K/ DDC8 functional antibody
Anti-TIMP2/ CSC-21K/ DDC8 functional antibody for cell culture, ELISA & in-vivo assay
Go to TIMP2/TIMP2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1338-Ab-1/ GM-Tg-hg-SE1338-Ab-2 | Anti-Human TIMP2 monoclonal antibody | Human |
| GM-Tg-rg-SE1338-Ab-1/ GM-Tg-rg-SE1338-Ab-2 | Anti-Rat TIMP2 monoclonal antibody | Rat |
| GM-Tg-mg-SE1338-Ab-1/ GM-Tg-mg-SE1338-Ab-2 | Anti-Mouse TIMP2 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1338-Ab-1/ GM-Tg-cynog-SE1338-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TIMP2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1338-Ab-1/ GM-Tg-felg-SE1338-Ab-2 | Anti-Feline TIMP2 monoclonal antibody | Feline |
| GM-Tg-cang-SE1338-Ab-1/ GM-Tg-cang-SE1338-Ab-2 | Anti-Canine TIMP2 monoclonal antibody | Canine |
| GM-Tg-bovg-SE1338-Ab-1/ GM-Tg-bovg-SE1338-Ab-2 | Anti-Bovine TIMP2 monoclonal antibody | Bovine |
| GM-Tg-equg-SE1338-Ab-1/ GM-Tg-equg-SE1338-Ab-2 | Anti-Equine TIMP2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1338-Ab-1/ GM-Tg-hg-SE1338-Ab-2; GM-Tg-rg-SE1338-Ab-1/ GM-Tg-rg-SE1338-Ab-2; GM-Tg-mg-SE1338-Ab-1/ GM-Tg-mg-SE1338-Ab-2; GM-Tg-cynog-SE1338-Ab-1/ GM-Tg-cynog-SE1338-Ab-2; GM-Tg-felg-SE1338-Ab-1/ GM-Tg-felg-SE1338-Ab-2; GM-Tg-cang-SE1338-Ab-1/ GM-Tg-cang-SE1338-Ab-2; GM-Tg-bovg-SE1338-Ab-1/ GM-Tg-bovg-SE1338-Ab-2; GM-Tg-equg-SE1338-Ab-1/ GM-Tg-equg-SE1338-Ab-2 |
| Products Name | Anti-TIMP2 monoclonal antibody |
| Format | mab |
| Target Name | TIMP2 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-TIMP2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1338-Ag-1 | Recombinant multi-species TIMP2/ CSC-21K/ DDC8 protein |
| ORF Viral Vector | vGMLP002009 | human TIMP2 Lentivirus particle |
| ORF Viral Vector | pGMLP002009 | human TIMP2 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm000991 | mouse Timp2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000991 | mouse Timp2 Lentivirus particle |
Target information
| Target ID | GM-SE1338 |
| Target Name | TIMP2 |
| Gene ID | 7077,21858,29543,574357,403633,101083125,282093,100034134 |
| Gene Symbol and Synonyms | CSC-21K,D11Bwg1104e,DDC8,Timp-2,TIMP2 |
| Uniprot Accession | P16035,P30121,Q9TTY1,P16368,O77717 |
| Uniprot Entry Name | TIMP2_HUMAN,TIMP2_RAT,TIMP2_CANLF,TIMP2_BOVIN,TIMP2_HORSE |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | Acute kidney failure, Dent disease, Malignant neoplasm of bladder |
| Gene Ensembl | ENSG00000035862 |
| Target Classification | N/A |
The target: TIMP2, gene name: TIMP2, also named as CSC-21K, DDC8. This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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