Anti-TINAG/ TIN-AG functional antibody

Anti-TINAG/ TIN-AG functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to TINAG/TINAG products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1341-Ab-1/ GM-Tg-hg-SE1341-Ab-2Anti-Human TINAG monoclonal antibodyHuman
GM-Tg-rg-SE1341-Ab-1/ GM-Tg-rg-SE1341-Ab-2Anti-Rat TINAG monoclonal antibodyRat
GM-Tg-mg-SE1341-Ab-1/ GM-Tg-mg-SE1341-Ab-2Anti-Mouse TINAG monoclonal antibodyMouse
GM-Tg-cynog-SE1341-Ab-1/ GM-Tg-cynog-SE1341-Ab-2Anti-Cynomolgus/ Rhesus macaque TINAG monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1341-Ab-1/ GM-Tg-felg-SE1341-Ab-2Anti-Feline TINAG monoclonal antibodyFeline
GM-Tg-cang-SE1341-Ab-1/ GM-Tg-cang-SE1341-Ab-2Anti-Canine TINAG monoclonal antibodyCanine
GM-Tg-bovg-SE1341-Ab-1/ GM-Tg-bovg-SE1341-Ab-2Anti-Bovine TINAG monoclonal antibodyBovine
GM-Tg-equg-SE1341-Ab-1/ GM-Tg-equg-SE1341-Ab-2Anti-Equine TINAG monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1341-Ab-1/ GM-Tg-hg-SE1341-Ab-2; GM-Tg-rg-SE1341-Ab-1/ GM-Tg-rg-SE1341-Ab-2;
GM-Tg-mg-SE1341-Ab-1/ GM-Tg-mg-SE1341-Ab-2; GM-Tg-cynog-SE1341-Ab-1/ GM-Tg-cynog-SE1341-Ab-2;
GM-Tg-felg-SE1341-Ab-1/ GM-Tg-felg-SE1341-Ab-2; GM-Tg-cang-SE1341-Ab-1/ GM-Tg-cang-SE1341-Ab-2;
GM-Tg-bovg-SE1341-Ab-1/ GM-Tg-bovg-SE1341-Ab-2; GM-Tg-equg-SE1341-Ab-1/ GM-Tg-equg-SE1341-Ab-2
Products NameAnti-TINAG monoclonal antibody
Formatmab
Target NameTINAG
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-TINAG benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1341-Ag-1Recombinant multi-species TINAG/ TIN-AG protein


    Target information

    Target IDGM-SE1341
    Target NameTINAG
    Gene ID27283,26944,300846,711185,481848,101087743,512517,100069589
    Gene Symbol and SynonymsTIN-AG,TINAG
    Uniprot AccessionQ9UJW2,Q3SZI1
    Uniprot Entry NameTINAG_HUMAN,TINAG_BOVIN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000137251
    Target ClassificationN/A

    The target: TINAG, gene name: TINAG, also named as TIN-AG. This gene encodes a glycoprotein that is restricted within the kidney to the basement membranes underlying the epithelium of Bowman's capsule and proximal and distal tubules. Autoantibodies against this protein are found in sera of patients with tubulointerstital nephritis, membranous nephropathy and anti-glomerular basement membrane nephritis. Ontogeny studies suggest that the expression of this antigen is developmentally regulated in a precise spatial and temporal pattern throughout nephrogenesis. [provided by RefSeq, Nov 2011].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.