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Anti-TNF6B/ TNFRSF6B/ DCR3 functional antibody
Anti-TNF6B/ TNFRSF6B/ DCR3 functional antibody for cell culture, ELISA & in-vivo assay
Go to TNFRSF6B/TNFRSF6B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1344-Ab-1/ GM-Tg-hg-SE1344-Ab-2 | Anti-Human TNFRSF6B monoclonal antibody | Human |
| GM-Tg-rg-SE1344-Ab-1/ GM-Tg-rg-SE1344-Ab-2 | Anti-Rat TNFRSF6B monoclonal antibody | Rat |
| GM-Tg-mg-SE1344-Ab-1/ GM-Tg-mg-SE1344-Ab-2 | Anti-Mouse TNFRSF6B monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1344-Ab-1/ GM-Tg-cynog-SE1344-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TNFRSF6B monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1344-Ab-1/ GM-Tg-felg-SE1344-Ab-2 | Anti-Feline TNFRSF6B monoclonal antibody | Feline |
| GM-Tg-cang-SE1344-Ab-1/ GM-Tg-cang-SE1344-Ab-2 | Anti-Canine TNFRSF6B monoclonal antibody | Canine |
| GM-Tg-bovg-SE1344-Ab-1/ GM-Tg-bovg-SE1344-Ab-2 | Anti-Bovine TNFRSF6B monoclonal antibody | Bovine |
| GM-Tg-equg-SE1344-Ab-1/ GM-Tg-equg-SE1344-Ab-2 | Anti-Equine TNFRSF6B monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1344-Ab-1/ GM-Tg-hg-SE1344-Ab-2; GM-Tg-rg-SE1344-Ab-1/ GM-Tg-rg-SE1344-Ab-2; GM-Tg-mg-SE1344-Ab-1/ GM-Tg-mg-SE1344-Ab-2; GM-Tg-cynog-SE1344-Ab-1/ GM-Tg-cynog-SE1344-Ab-2; GM-Tg-felg-SE1344-Ab-1/ GM-Tg-felg-SE1344-Ab-2; GM-Tg-cang-SE1344-Ab-1/ GM-Tg-cang-SE1344-Ab-2; GM-Tg-bovg-SE1344-Ab-1/ GM-Tg-bovg-SE1344-Ab-2; GM-Tg-equg-SE1344-Ab-1/ GM-Tg-equg-SE1344-Ab-2 |
| Products Name | Anti-TNFRSF6B monoclonal antibody |
| Format | mab |
| Target Name | TNFRSF6B |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-TNFRSF6B benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1344-Ag-1 | Recombinant multi-species TNF6B/ TNFRSF6B/ DCR3 protein |
| Cytokine | GM-Tg-g-SE1344-Ag-1 | tumor necrosis factor receptor superfamily, member 6b, decoy (TNFRSF6B) protein |
| ORF Viral Vector | pGMLP004983 | human TNFRSF6B Lentivirus plasmid |
| ORF Viral Vector | vGMLP004983 | human TNFRSF6B Lentivirus particle |
Target information
| Target ID | GM-SE1344 |
| Target Name | TNFRSF6B |
| Gene ID | 8771,114669829,119865736,102899242,789154,111770055 |
| Gene Symbol and Synonyms | DCR3,DJ583P15.1.1,M68,M68E,TNFRSF6B,TR6 |
| Uniprot Accession | O95407 |
| Uniprot Entry Name | TNF6B_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Cytokine Target |
| Disease | Colon Cancer |
| Gene Ensembl | ENSG00000243509 |
| Target Classification | N/A |
The target: TNFRSF6B, gene name: TNFRSF6B, also named as DCR3, DJ583P15.1.1, M68, M68E, TR6. This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript. [provided by RefSeq, Feb 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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