Anti-TENN/ TNN/ TN-W functional antibody

Anti-TENN/ TNN/ TN-W functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to TNN/TNN products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1345-Ab-1/ GM-Tg-hg-SE1345-Ab-2Anti-Human TNN monoclonal antibodyHuman
GM-Tg-rg-SE1345-Ab-1/ GM-Tg-rg-SE1345-Ab-2Anti-Rat TNN monoclonal antibodyRat
GM-Tg-mg-SE1345-Ab-1/ GM-Tg-mg-SE1345-Ab-2Anti-Mouse TNN monoclonal antibodyMouse
GM-Tg-cynog-SE1345-Ab-1/ GM-Tg-cynog-SE1345-Ab-2Anti-Cynomolgus/ Rhesus macaque TNN monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1345-Ab-1/ GM-Tg-felg-SE1345-Ab-2Anti-Feline TNN monoclonal antibodyFeline
GM-Tg-cang-SE1345-Ab-1/ GM-Tg-cang-SE1345-Ab-2Anti-Canine TNN monoclonal antibodyCanine
GM-Tg-bovg-SE1345-Ab-1/ GM-Tg-bovg-SE1345-Ab-2Anti-Bovine TNN monoclonal antibodyBovine
GM-Tg-equg-SE1345-Ab-1/ GM-Tg-equg-SE1345-Ab-2Anti-Equine TNN monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1345-Ab-1/ GM-Tg-hg-SE1345-Ab-2; GM-Tg-rg-SE1345-Ab-1/ GM-Tg-rg-SE1345-Ab-2;
GM-Tg-mg-SE1345-Ab-1/ GM-Tg-mg-SE1345-Ab-2; GM-Tg-cynog-SE1345-Ab-1/ GM-Tg-cynog-SE1345-Ab-2;
GM-Tg-felg-SE1345-Ab-1/ GM-Tg-felg-SE1345-Ab-2; GM-Tg-cang-SE1345-Ab-1/ GM-Tg-cang-SE1345-Ab-2;
GM-Tg-bovg-SE1345-Ab-1/ GM-Tg-bovg-SE1345-Ab-2; GM-Tg-equg-SE1345-Ab-1/ GM-Tg-equg-SE1345-Ab-2
Products NameAnti-TNN monoclonal antibody
Formatmab
Target NameTNN
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-TNN benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1345-Ag-1Recombinant multi-species TENN/ TNN/ TN-W protein


    Target information

    Target IDGM-SE1345
    Target NameTNN
    Gene ID63923,329278,304913,708587,490335,101097863,517433,100061556
    Gene Symbol and Synonymstenascin-W,TN-W,TNN,TNW
    Uniprot AccessionQ9UQP3
    Uniprot Entry NameTENN_HUMAN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000120332
    Target ClassificationN/A

    The target: TNN, gene name: TNN, also named as TN-W. Predicted to enable integrin binding activity. Predicted to be involved in several processes, including generation of neurons; negative regulation of canonical Wnt signaling pathway involved in osteoblast differentiation; and negative regulation of osteoblast differentiation. Predicted to act upstream of or within axonogenesis. Predicted to be located in extracellular matrix and neuron projection. Predicted to be active in collagen-containing extracellular matrix and extracellular space. [provided by Alliance of Genome Resources, Apr 2022].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.