Anti-TSK/ TSKU/ E2IG4 functional antibody

Anti-TSK/ TSKU/ E2IG4 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to TSKU/TSKU products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1349-Ab-1/ GM-Tg-hg-SE1349-Ab-2Anti-Human TSKU monoclonal antibodyHuman
GM-Tg-rg-SE1349-Ab-1/ GM-Tg-rg-SE1349-Ab-2Anti-Rat TSKU monoclonal antibodyRat
GM-Tg-mg-SE1349-Ab-1/ GM-Tg-mg-SE1349-Ab-2Anti-Mouse TSKU monoclonal antibodyMouse
GM-Tg-cynog-SE1349-Ab-1/ GM-Tg-cynog-SE1349-Ab-2Anti-Cynomolgus/ Rhesus macaque TSKU monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1349-Ab-1/ GM-Tg-felg-SE1349-Ab-2Anti-Feline TSKU monoclonal antibodyFeline
GM-Tg-cang-SE1349-Ab-1/ GM-Tg-cang-SE1349-Ab-2Anti-Canine TSKU monoclonal antibodyCanine
GM-Tg-bovg-SE1349-Ab-1/ GM-Tg-bovg-SE1349-Ab-2Anti-Bovine TSKU monoclonal antibodyBovine
GM-Tg-equg-SE1349-Ab-1/ GM-Tg-equg-SE1349-Ab-2Anti-Equine TSKU monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1349-Ab-1/ GM-Tg-hg-SE1349-Ab-2; GM-Tg-rg-SE1349-Ab-1/ GM-Tg-rg-SE1349-Ab-2;
GM-Tg-mg-SE1349-Ab-1/ GM-Tg-mg-SE1349-Ab-2; GM-Tg-cynog-SE1349-Ab-1/ GM-Tg-cynog-SE1349-Ab-2;
GM-Tg-felg-SE1349-Ab-1/ GM-Tg-felg-SE1349-Ab-2; GM-Tg-cang-SE1349-Ab-1/ GM-Tg-cang-SE1349-Ab-2;
GM-Tg-bovg-SE1349-Ab-1/ GM-Tg-bovg-SE1349-Ab-2; GM-Tg-equg-SE1349-Ab-1/ GM-Tg-equg-SE1349-Ab-2
Products NameAnti-TSKU monoclonal antibody
Formatmab
Target NameTSKU
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-TSKU benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1349-Ag-1Recombinant multi-species TSK/ TSKU/ E2IG4 protein


    Target information

    Target IDGM-SE1349
    Target NameTSKU
    Gene ID25987,244152,308843,697691,485178,101089390,529661,100063671
    Gene Symbol and Synonyms9530051K01Rik,E2IG4,Eiih,LRRC54,TSK,TSKU
    Uniprot AccessionQ8WUA8,Q6QMY6
    Uniprot Entry NameTSK_HUMAN,TSK_RAT
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000182704
    Target ClassificationN/A

    The target: TSKU, gene name: TSKU, also named as E2IG4, LRRC54, TSK. Predicted to enable transforming growth factor beta binding activity. Predicted to be involved in several processes, including animal organ development; cholesterol efflux; and cholesterol homeostasis. Predicted to act upstream of or within several processes, including ciliary body morphogenesis; negative regulation of Wnt signaling pathway; and telencephalon development. Predicted to be located in extracellular space. [provided by Alliance of Genome Resources, Apr 2022].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.