Anti-TWSG1/ TSG functional antibody

Anti-TWSG1/ TSG functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to TWSG1/TWSG1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1354-Ab-1/ GM-Tg-hg-SE1354-Ab-2Anti-Human TWSG1 monoclonal antibodyHuman
GM-Tg-rg-SE1354-Ab-1/ GM-Tg-rg-SE1354-Ab-2Anti-Rat TWSG1 monoclonal antibodyRat
GM-Tg-mg-SE1354-Ab-1/ GM-Tg-mg-SE1354-Ab-2Anti-Mouse TWSG1 monoclonal antibodyMouse
GM-Tg-cynog-SE1354-Ab-1/ GM-Tg-cynog-SE1354-Ab-2Anti-Cynomolgus/ Rhesus macaque TWSG1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1354-Ab-1/ GM-Tg-felg-SE1354-Ab-2Anti-Feline TWSG1 monoclonal antibodyFeline
GM-Tg-cang-SE1354-Ab-1/ GM-Tg-cang-SE1354-Ab-2Anti-Canine TWSG1 monoclonal antibodyCanine
GM-Tg-bovg-SE1354-Ab-1/ GM-Tg-bovg-SE1354-Ab-2Anti-Bovine TWSG1 monoclonal antibodyBovine
GM-Tg-equg-SE1354-Ab-1/ GM-Tg-equg-SE1354-Ab-2Anti-Equine TWSG1 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1354-Ab-1/ GM-Tg-hg-SE1354-Ab-2; GM-Tg-rg-SE1354-Ab-1/ GM-Tg-rg-SE1354-Ab-2;
GM-Tg-mg-SE1354-Ab-1/ GM-Tg-mg-SE1354-Ab-2; GM-Tg-cynog-SE1354-Ab-1/ GM-Tg-cynog-SE1354-Ab-2;
GM-Tg-felg-SE1354-Ab-1/ GM-Tg-felg-SE1354-Ab-2; GM-Tg-cang-SE1354-Ab-1/ GM-Tg-cang-SE1354-Ab-2;
GM-Tg-bovg-SE1354-Ab-1/ GM-Tg-bovg-SE1354-Ab-2; GM-Tg-equg-SE1354-Ab-1/ GM-Tg-equg-SE1354-Ab-2
Products NameAnti-TWSG1 monoclonal antibody
Formatmab
Target NameTWSG1
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-TWSG1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1354-Ag-1Recombinant multi-species TWSG1/ TSG protein
    ORF Viral VectorpGMLP005078human TWSG1 Lentivirus plasmid
    ORF Viral VectorvGMLP005078human TWSG1 Lentivirus particle
    ORF Viral VectorpGMLPm003472mouse Twsg1 Lentivirus plasmid
    ORF Viral VectorvGMLPm003472mouse Twsg1 Lentivirus particle


    Target information

    Target IDGM-SE1354
    Target NameTWSG1
    Gene ID57045,65960,363294,705804,490546,101101257,537290,100054712
    Gene Symbol and Synonyms1810013J15Rik,9030422N06Rik,D17Ertd403e,TSG,Twg,TWSG1
    Uniprot AccessionQ9GZX9
    Uniprot Entry NameTWSG1_HUMAN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000128791
    Target ClassificationN/A

    The target: TWSG1, gene name: TWSG1, also named as TSG. Enables transforming growth factor beta binding activity. Involved in several processes, including negative regulation of CD4-positive, alpha-beta T cell proliferation; positive regulation of pathway-restricted SMAD protein phosphorylation; and transforming growth factor beta receptor signaling pathway. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.