Anti-UTS2/ PRO1068/ U-II functional antibody
Anti-UTS2/ PRO1068/ U-II functional antibody for cell culture, ELISA & in-vivo assay
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-SE1358-Ab-1/ GM-Tg-hg-SE1358-Ab-2 | Anti-Human UTS2 monoclonal antibody | Human |
GM-Tg-rg-SE1358-Ab-1/ GM-Tg-rg-SE1358-Ab-2 | Anti-Rat UTS2 monoclonal antibody | Rat |
GM-Tg-mg-SE1358-Ab-1/ GM-Tg-mg-SE1358-Ab-2 | Anti-Mouse UTS2 monoclonal antibody | Mouse |
GM-Tg-cynog-SE1358-Ab-1/ GM-Tg-cynog-SE1358-Ab-2 | Anti-Cynomolgus/ Rhesus macaque UTS2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-SE1358-Ab-1/ GM-Tg-felg-SE1358-Ab-2 | Anti-Feline UTS2 monoclonal antibody | Feline |
GM-Tg-cang-SE1358-Ab-1/ GM-Tg-cang-SE1358-Ab-2 | Anti-Canine UTS2 monoclonal antibody | Canine |
GM-Tg-bovg-SE1358-Ab-1/ GM-Tg-bovg-SE1358-Ab-2 | Anti-Bovine UTS2 monoclonal antibody | Bovine |
GM-Tg-equg-SE1358-Ab-1/ GM-Tg-equg-SE1358-Ab-2 | Anti-Equine UTS2 monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-SE1358-Ab-1/ GM-Tg-hg-SE1358-Ab-2; GM-Tg-rg-SE1358-Ab-1/ GM-Tg-rg-SE1358-Ab-2; GM-Tg-mg-SE1358-Ab-1/ GM-Tg-mg-SE1358-Ab-2; GM-Tg-cynog-SE1358-Ab-1/ GM-Tg-cynog-SE1358-Ab-2; GM-Tg-felg-SE1358-Ab-1/ GM-Tg-felg-SE1358-Ab-2; GM-Tg-cang-SE1358-Ab-1/ GM-Tg-cang-SE1358-Ab-2; GM-Tg-bovg-SE1358-Ab-1/ GM-Tg-bovg-SE1358-Ab-2; GM-Tg-equg-SE1358-Ab-1/ GM-Tg-equg-SE1358-Ab-2 |
Products Name | Anti-UTS2 monoclonal antibody |
Format | mab |
Target Name | UTS2 |
Protein Sub-location | Secreted Protein/Potential Cytokines |
Category of antibody | FACS/Biofunctional Antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-UTS2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | GM-Tg-g-SE1358-Ag-1 | Recombinant multi-species UTS2/ PRO1068/ U-II protein |
ORF Viral Vector | pGMLPm004530 | mouse Uts2 Lentivirus plasmid |
ORF Viral Vector | vGMLPm004530 | mouse Uts2 Lentivirus particle |
Target information
Target ID | GM-SE1358 |
Target Name | UTS2 |
Gene ID | 10911,24111,29180,574246,102154221,101096330,100295833,102148801 |
Gene Symbol and Synonyms | prepro-UII,PRO1068,U-II,UCN2,UII,UTS2 |
Uniprot Accession | O95399,Q9QZQ4,Q8HYC2 |
Uniprot Entry Name | UTS2_HUMAN,UTS2_MACMU,UTS2_RAT |
Protein Sub-location | Secreted Protein/Potential Cytokines |
Category | |
Disease | N/A |
Gene Ensembl | ENSG00000049247 |
Target Classification | N/A |
The target: UTS2, gene name: UTS2, also named as PRO1068, U-II, UCN2, UII. This gene encodes a mature peptide that is an active cyclic heptapeptide absolutely conserved from lamprey to human. The active peptide acts as a vasoconstrictor and is expressed only in brain tissue. Despite the gene family name similarity, this gene is not homologous to urocortin, a member of the sauvagine/corticotropin-releasing factor/urotensin I family. Most of the proprotein is cleaved to make the mature peptide. Transcript variants encoding different preproprotein isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.