Anti-UTS2/ PRO1068/ U-II functional antibody

Anti-UTS2/ PRO1068/ U-II functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to UTS2/UTS2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1358-Ab-1/ GM-Tg-hg-SE1358-Ab-2Anti-Human UTS2 monoclonal antibodyHuman
GM-Tg-rg-SE1358-Ab-1/ GM-Tg-rg-SE1358-Ab-2Anti-Rat UTS2 monoclonal antibodyRat
GM-Tg-mg-SE1358-Ab-1/ GM-Tg-mg-SE1358-Ab-2Anti-Mouse UTS2 monoclonal antibodyMouse
GM-Tg-cynog-SE1358-Ab-1/ GM-Tg-cynog-SE1358-Ab-2Anti-Cynomolgus/ Rhesus macaque UTS2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1358-Ab-1/ GM-Tg-felg-SE1358-Ab-2Anti-Feline UTS2 monoclonal antibodyFeline
GM-Tg-cang-SE1358-Ab-1/ GM-Tg-cang-SE1358-Ab-2Anti-Canine UTS2 monoclonal antibodyCanine
GM-Tg-bovg-SE1358-Ab-1/ GM-Tg-bovg-SE1358-Ab-2Anti-Bovine UTS2 monoclonal antibodyBovine
GM-Tg-equg-SE1358-Ab-1/ GM-Tg-equg-SE1358-Ab-2Anti-Equine UTS2 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1358-Ab-1/ GM-Tg-hg-SE1358-Ab-2; GM-Tg-rg-SE1358-Ab-1/ GM-Tg-rg-SE1358-Ab-2;
GM-Tg-mg-SE1358-Ab-1/ GM-Tg-mg-SE1358-Ab-2; GM-Tg-cynog-SE1358-Ab-1/ GM-Tg-cynog-SE1358-Ab-2;
GM-Tg-felg-SE1358-Ab-1/ GM-Tg-felg-SE1358-Ab-2; GM-Tg-cang-SE1358-Ab-1/ GM-Tg-cang-SE1358-Ab-2;
GM-Tg-bovg-SE1358-Ab-1/ GM-Tg-bovg-SE1358-Ab-2; GM-Tg-equg-SE1358-Ab-1/ GM-Tg-equg-SE1358-Ab-2
Products NameAnti-UTS2 monoclonal antibody
Formatmab
Target NameUTS2
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-UTS2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1358-Ag-1Recombinant multi-species UTS2/ PRO1068/ U-II protein
    ORF Viral VectorpGMLPm004530mouse Uts2 Lentivirus plasmid
    ORF Viral VectorvGMLPm004530mouse Uts2 Lentivirus particle


    Target information

    Target IDGM-SE1358
    Target NameUTS2
    Gene ID10911,24111,29180,574246,102154221,101096330,100295833,102148801
    Gene Symbol and Synonymsprepro-UII,PRO1068,U-II,UCN2,UII,UTS2
    Uniprot AccessionO95399,Q9QZQ4,Q8HYC2
    Uniprot Entry NameUTS2_HUMAN,UTS2_MACMU,UTS2_RAT
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000049247
    Target ClassificationN/A

    The target: UTS2, gene name: UTS2, also named as PRO1068, U-II, UCN2, UII. This gene encodes a mature peptide that is an active cyclic heptapeptide absolutely conserved from lamprey to human. The active peptide acts as a vasoconstrictor and is expressed only in brain tissue. Despite the gene family name similarity, this gene is not homologous to urocortin, a member of the sauvagine/corticotropin-releasing factor/urotensin I family. Most of the proprotein is cleaved to make the mature peptide. Transcript variants encoding different preproprotein isoforms have been described for this gene. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.