Anti-WFDC1/ PS20 functional antibody

Anti-WFDC1/ PS20 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to WFDC1/WFDC1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1372-Ab-1/ GM-Tg-hg-SE1372-Ab-2Anti-Human WFDC1 monoclonal antibodyHuman
GM-Tg-rg-SE1372-Ab-1/ GM-Tg-rg-SE1372-Ab-2Anti-Rat WFDC1 monoclonal antibodyRat
GM-Tg-mg-SE1372-Ab-1/ GM-Tg-mg-SE1372-Ab-2Anti-Mouse WFDC1 monoclonal antibodyMouse
GM-Tg-cynog-SE1372-Ab-1/ GM-Tg-cynog-SE1372-Ab-2Anti-Cynomolgus/ Rhesus macaque WFDC1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1372-Ab-1/ GM-Tg-felg-SE1372-Ab-2Anti-Feline WFDC1 monoclonal antibodyFeline
GM-Tg-cang-SE1372-Ab-1/ GM-Tg-cang-SE1372-Ab-2Anti-Canine WFDC1 monoclonal antibodyCanine
GM-Tg-bovg-SE1372-Ab-1/ GM-Tg-bovg-SE1372-Ab-2Anti-Bovine WFDC1 monoclonal antibodyBovine
GM-Tg-equg-SE1372-Ab-1/ GM-Tg-equg-SE1372-Ab-2Anti-Equine WFDC1 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1372-Ab-1/ GM-Tg-hg-SE1372-Ab-2; GM-Tg-rg-SE1372-Ab-1/ GM-Tg-rg-SE1372-Ab-2;
GM-Tg-mg-SE1372-Ab-1/ GM-Tg-mg-SE1372-Ab-2; GM-Tg-cynog-SE1372-Ab-1/ GM-Tg-cynog-SE1372-Ab-2;
GM-Tg-felg-SE1372-Ab-1/ GM-Tg-felg-SE1372-Ab-2; GM-Tg-cang-SE1372-Ab-1/ GM-Tg-cang-SE1372-Ab-2;
GM-Tg-bovg-SE1372-Ab-1/ GM-Tg-bovg-SE1372-Ab-2; GM-Tg-equg-SE1372-Ab-1/ GM-Tg-equg-SE1372-Ab-2
Products NameAnti-WFDC1 monoclonal antibody
Formatmab
Target NameWFDC1
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-WFDC1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1372-Ag-1Recombinant multi-species WFDC1/ PS20 protein


    Target information

    Target IDGM-SE1372
    Target NameWFDC1
    Gene ID58189,67866,171112,715230,489682,101088637,505366,100070154
    Gene Symbol and Synonyms2310058A03Rik,PS20,WFDC1
    Uniprot AccessionQ9HC57,O70280
    Uniprot Entry NameWFDC1_HUMAN,WFDC1_RAT
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000103175
    Target ClassificationN/A

    The target: WFDC1, gene name: WFDC1, also named as PS20. This gene encodes a member of the WAP-type four disulfide core domain family. The WAP-type four-disulfide core domain contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is mapped to chromosome 16q24, an area of frequent loss of heterozygosity in cancers, including prostate, breast and hepatocellular cancers and Wilms' tumor. This gene is downregulated in many cancer types and may be involved in the inhibition of cell proliferation. The encoded protein may also play a role in the susceptibility of certain CD4 memory T cells to human immunodeficiency virus infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.