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Anti-NADC/ QPRT/ HEL-S-90nase functional antibody
Anti-NADC/ QPRT/ HEL-S-90nase functional antibody for cell culture, ELISA & in-vivo assay
Go to QPRT/QPRT products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1390-Ab-1/ GM-Tg-hg-SE1390-Ab-2 | Anti-Human QPRT monoclonal antibody | Human |
| GM-Tg-rg-SE1390-Ab-1/ GM-Tg-rg-SE1390-Ab-2 | Anti-Rat QPRT monoclonal antibody | Rat |
| GM-Tg-mg-SE1390-Ab-1/ GM-Tg-mg-SE1390-Ab-2 | Anti-Mouse QPRT monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1390-Ab-1/ GM-Tg-cynog-SE1390-Ab-2 | Anti-Cynomolgus/ Rhesus macaque QPRT monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1390-Ab-1/ GM-Tg-felg-SE1390-Ab-2 | Anti-Feline QPRT monoclonal antibody | Feline |
| GM-Tg-cang-SE1390-Ab-1/ GM-Tg-cang-SE1390-Ab-2 | Anti-Canine QPRT monoclonal antibody | Canine |
| GM-Tg-bovg-SE1390-Ab-1/ GM-Tg-bovg-SE1390-Ab-2 | Anti-Bovine QPRT monoclonal antibody | Bovine |
| GM-Tg-equg-SE1390-Ab-1/ GM-Tg-equg-SE1390-Ab-2 | Anti-Equine QPRT monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1390-Ab-1/ GM-Tg-hg-SE1390-Ab-2; GM-Tg-rg-SE1390-Ab-1/ GM-Tg-rg-SE1390-Ab-2; GM-Tg-mg-SE1390-Ab-1/ GM-Tg-mg-SE1390-Ab-2; GM-Tg-cynog-SE1390-Ab-1/ GM-Tg-cynog-SE1390-Ab-2; GM-Tg-felg-SE1390-Ab-1/ GM-Tg-felg-SE1390-Ab-2; GM-Tg-cang-SE1390-Ab-1/ GM-Tg-cang-SE1390-Ab-2; GM-Tg-bovg-SE1390-Ab-1/ GM-Tg-bovg-SE1390-Ab-2; GM-Tg-equg-SE1390-Ab-1/ GM-Tg-equg-SE1390-Ab-2 |
| Products Name | Anti-QPRT monoclonal antibody |
| Format | mab |
| Target Name | QPRT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-QPRT benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1390-Ag-1 | Recombinant multi-species NADC/ QPRT/ HEL-S-90nase protein |
Target information
| Target ID | GM-SE1390 |
| Target Name | QPRT |
| Gene ID | 23475,67375,293504,708784,607664,101087441,614254,100065768 |
| Gene Symbol and Synonyms | 2410027J01Rik,HEL-S-90n,QPRT,QPRTase |
| Uniprot Accession | Q15274,Q5I0M2,Q3T063 |
| Uniprot Entry Name | NADC_HUMAN,NADC_RAT,NADC_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000103485 |
| Target Classification | N/A |
The target: QPRT, gene name: QPRT, also named as HEL-S-90nase, QPRT. This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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