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Anti-CP26B/ CYP26B1/ CYP26A2 functional antibody
Anti-CP26B/ CYP26B1/ CYP26A2 functional antibody for cell culture, ELISA & in-vivo assay
Go to CYP26B1/CYP26B1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1395-Ab-1/ GM-Tg-hg-SE1395-Ab-2 | Anti-Human CYP26B1 monoclonal antibody | Human |
| GM-Tg-rg-SE1395-Ab-1/ GM-Tg-rg-SE1395-Ab-2 | Anti-Rat CYP26B1 monoclonal antibody | Rat |
| GM-Tg-mg-SE1395-Ab-1/ GM-Tg-mg-SE1395-Ab-2 | Anti-Mouse CYP26B1 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1395-Ab-1/ GM-Tg-cynog-SE1395-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CYP26B1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1395-Ab-1/ GM-Tg-felg-SE1395-Ab-2 | Anti-Feline CYP26B1 monoclonal antibody | Feline |
| GM-Tg-cang-SE1395-Ab-1/ GM-Tg-cang-SE1395-Ab-2 | Anti-Canine CYP26B1 monoclonal antibody | Canine |
| GM-Tg-bovg-SE1395-Ab-1/ GM-Tg-bovg-SE1395-Ab-2 | Anti-Bovine CYP26B1 monoclonal antibody | Bovine |
| GM-Tg-equg-SE1395-Ab-1/ GM-Tg-equg-SE1395-Ab-2 | Anti-Equine CYP26B1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1395-Ab-1/ GM-Tg-hg-SE1395-Ab-2; GM-Tg-rg-SE1395-Ab-1/ GM-Tg-rg-SE1395-Ab-2; GM-Tg-mg-SE1395-Ab-1/ GM-Tg-mg-SE1395-Ab-2; GM-Tg-cynog-SE1395-Ab-1/ GM-Tg-cynog-SE1395-Ab-2; GM-Tg-felg-SE1395-Ab-1/ GM-Tg-felg-SE1395-Ab-2; GM-Tg-cang-SE1395-Ab-1/ GM-Tg-cang-SE1395-Ab-2; GM-Tg-bovg-SE1395-Ab-1/ GM-Tg-bovg-SE1395-Ab-2; GM-Tg-equg-SE1395-Ab-1/ GM-Tg-equg-SE1395-Ab-2 |
| Products Name | Anti-CYP26B1 monoclonal antibody |
| Format | mab |
| Target Name | CYP26B1 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CYP26B1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1395-Ag-1 | Recombinant multi-species CP26B/ CYP26B1/ CYP26A2 protein |
| ORF Viral Vector | pGMLPm003161 | mouse Cyp26b1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003161 | mouse Cyp26b1 Lentivirus particle |
Target information
| Target ID | GM-SE1395 |
| Target Name | CYP26B1 |
| Gene ID | 56603,232174,312495,704750,483120,101100712,540868,100059609 |
| Gene Symbol and Synonyms | CP26,CYP26A2,CYP26B1,P450RAI-2,P450RAI2,RHFCA |
| Uniprot Accession | Q9NR63,G3V7X8,E1BHJ4 |
| Uniprot Entry Name | CP26B_HUMAN,CP26B_RAT,CP26B_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000003137 |
| Target Classification | N/A |
The target: CYP26B1, gene name: CYP26B1, also named as CYP26A2, P450RAI-2, P450RAI2, RHFCA. This gene encodes a member of the cytochrome P450 superfamily. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein is localized to the endoplasmic reticulum, and functions as a critical regulator of all-trans retinoic acid levels by the specific inactivation of all-trans retinoic acid to hydroxylated forms. Mutations in this gene are associated with radiohumeral fusions and other skeletal and craniofacial anomalies, and increased levels of the encoded protein are associated with atherosclerotic lesions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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