- • Up to 20% off your first purchase
- • Bulk quantities available
- • Citation Reward application
Sample Application
- Animal health test
- In-vitro diagnostics
- Food & Feed Safety
- Environmental Safety
- New drug discovery
Supports
- Talk to our Expert:
[email protected] -
Talk to our sales:
[email protected]
Protocol Library Download
 |
 |
Anti-ODBB/ BCKDHB/ BCKDE1B functional antibody
Anti-ODBB/ BCKDHB/ BCKDE1B functional antibody for cell culture, ELISA & in-vivo assay
Go to BCKDHB/BCKDHB products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1424-Ab-1/ GM-Tg-hg-SE1424-Ab-2 | Anti-Human BCKDHB monoclonal antibody | Human |
| GM-Tg-rg-SE1424-Ab-1/ GM-Tg-rg-SE1424-Ab-2 | Anti-Rat BCKDHB monoclonal antibody | Rat |
| GM-Tg-mg-SE1424-Ab-1/ GM-Tg-mg-SE1424-Ab-2 | Anti-Mouse BCKDHB monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1424-Ab-1/ GM-Tg-cynog-SE1424-Ab-2 | Anti-Cynomolgus/ Rhesus macaque BCKDHB monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1424-Ab-1/ GM-Tg-felg-SE1424-Ab-2 | Anti-Feline BCKDHB monoclonal antibody | Feline |
| GM-Tg-cang-SE1424-Ab-1/ GM-Tg-cang-SE1424-Ab-2 | Anti-Canine BCKDHB monoclonal antibody | Canine |
| GM-Tg-bovg-SE1424-Ab-1/ GM-Tg-bovg-SE1424-Ab-2 | Anti-Bovine BCKDHB monoclonal antibody | Bovine |
| GM-Tg-equg-SE1424-Ab-1/ GM-Tg-equg-SE1424-Ab-2 | Anti-Equine BCKDHB monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1424-Ab-1/ GM-Tg-hg-SE1424-Ab-2; GM-Tg-rg-SE1424-Ab-1/ GM-Tg-rg-SE1424-Ab-2; GM-Tg-mg-SE1424-Ab-1/ GM-Tg-mg-SE1424-Ab-2; GM-Tg-cynog-SE1424-Ab-1/ GM-Tg-cynog-SE1424-Ab-2; GM-Tg-felg-SE1424-Ab-1/ GM-Tg-felg-SE1424-Ab-2; GM-Tg-cang-SE1424-Ab-1/ GM-Tg-cang-SE1424-Ab-2; GM-Tg-bovg-SE1424-Ab-1/ GM-Tg-bovg-SE1424-Ab-2; GM-Tg-equg-SE1424-Ab-1/ GM-Tg-equg-SE1424-Ab-2 |
| Products Name | Anti-BCKDHB monoclonal antibody |
| Format | mab |
| Target Name | BCKDHB |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-BCKDHB benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1424-Ag-1 | Recombinant multi-species ODBB/ BCKDHB/ BCKDE1B protein |
Target information
| Target ID | GM-SE1424 |
| Target Name | BCKDHB |
| Gene ID | 594,12040,29711,718472,474978,101080635,282150,100065300 |
| Gene Symbol and Synonyms | BCKDE1B,BCKDH E1-beta,BCKDHB,E1B |
| Uniprot Accession | P21953,P35738,P21839 |
| Uniprot Entry Name | ODBB_HUMAN,ODBB_RAT,ODBB_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000083123 |
| Target Classification | N/A |
The target: BCKDHB, gene name: BCKDHB, also named as BCKDE1B, BCKDH E1-beta, E1B. This gene encodes the E1 beta subunit of branched-chain keto acid dehydrogenase, which is a multienzyme complex associated with the inner membrane of mitochondria. This enzyme complex functions in the catabolism of branched-chain amino acids. Mutations in this gene have been associated with maple syrup urine disease (MSUD), type 1B, a disease characterized by a maple syrup odor to the urine in addition to mental and physical retardation and feeding problems. Alternative splicing at this locus results in multiple transcript variants. [provided by RefSeq, Jan 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
Facebook
LinkedIn
Twitter
