Anti-P3H2/ LEPREL1/ MCVD functional antibody
Anti-P3H2/ LEPREL1/ MCVD functional antibody for cell culture, ELISA & in-vivo assay
Go to P3H2/P3H2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-SE1432-Ab-1/ GM-Tg-hg-SE1432-Ab-2 | Anti-Human P3H2 monoclonal antibody | Human |
GM-Tg-rg-SE1432-Ab-1/ GM-Tg-rg-SE1432-Ab-2 | Anti-Rat P3H2 monoclonal antibody | Rat |
GM-Tg-mg-SE1432-Ab-1/ GM-Tg-mg-SE1432-Ab-2 | Anti-Mouse P3H2 monoclonal antibody | Mouse |
GM-Tg-cynog-SE1432-Ab-1/ GM-Tg-cynog-SE1432-Ab-2 | Anti-Cynomolgus/ Rhesus macaque P3H2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-SE1432-Ab-1/ GM-Tg-felg-SE1432-Ab-2 | Anti-Feline P3H2 monoclonal antibody | Feline |
GM-Tg-cang-SE1432-Ab-1/ GM-Tg-cang-SE1432-Ab-2 | Anti-Canine P3H2 monoclonal antibody | Canine |
GM-Tg-bovg-SE1432-Ab-1/ GM-Tg-bovg-SE1432-Ab-2 | Anti-Bovine P3H2 monoclonal antibody | Bovine |
GM-Tg-equg-SE1432-Ab-1/ GM-Tg-equg-SE1432-Ab-2 | Anti-Equine P3H2 monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-SE1432-Ab-1/ GM-Tg-hg-SE1432-Ab-2; GM-Tg-rg-SE1432-Ab-1/ GM-Tg-rg-SE1432-Ab-2; GM-Tg-mg-SE1432-Ab-1/ GM-Tg-mg-SE1432-Ab-2; GM-Tg-cynog-SE1432-Ab-1/ GM-Tg-cynog-SE1432-Ab-2; GM-Tg-felg-SE1432-Ab-1/ GM-Tg-felg-SE1432-Ab-2; GM-Tg-cang-SE1432-Ab-1/ GM-Tg-cang-SE1432-Ab-2; GM-Tg-bovg-SE1432-Ab-1/ GM-Tg-bovg-SE1432-Ab-2; GM-Tg-equg-SE1432-Ab-1/ GM-Tg-equg-SE1432-Ab-2 |
Products Name | Anti-P3H2 monoclonal antibody |
Format | mab |
Target Name | P3H2 |
Protein Sub-location | Secreted Protein/Potential Cytokines |
Category of antibody | FACS/Biofunctional Antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-P3H2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | GM-Tg-g-SE1432-Ag-1 | Recombinant multi-species P3H2/ LEPREL1/ MCVD protein |
Target information
Target ID | GM-SE1432 |
Target Name | P3H2 |
Gene ID | 55214,210530,288016,704118,478674,101094873,511799,100059777 |
Gene Symbol and Synonyms | 4832416N06,LEPREL1,MCVD,MLAT4,P3H2 |
Uniprot Accession | Q8IVL5,Q4KLM6 |
Uniprot Entry Name | P3H2_HUMAN,P3H2_RAT |
Protein Sub-location | Secreted Protein/Potential Cytokines |
Category | |
Disease | N/A |
Gene Ensembl | ENSG00000090530 |
Target Classification | N/A |
The target: P3H2, gene name: P3H2, also named as LEPREL1, MCVD, MLAT4. This gene encodes a member of the prolyl 3-hydroxylase subfamily of 2-oxo-glutarate-dependent dioxygenases. These enzymes play a critical role in collagen chain assembly, stability and cross-linking by catalyzing post-translational 3-hydroxylation of proline residues. Mutations in this gene are associated with nonsyndromic severe myopia with cataract and vitreoretinal degeneration, and downregulation of this gene may play a role in breast cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.