Anti-UBP11/ USP11/ UHX1 functional antibody

Anti-UBP11/ USP11/ UHX1 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to USP11/USP11 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1441-Ab-1/ GM-Tg-hg-SE1441-Ab-2Anti-Human USP11 monoclonal antibodyHuman
GM-Tg-rg-SE1441-Ab-1/ GM-Tg-rg-SE1441-Ab-2Anti-Rat USP11 monoclonal antibodyRat
GM-Tg-mg-SE1441-Ab-1/ GM-Tg-mg-SE1441-Ab-2Anti-Mouse USP11 monoclonal antibodyMouse
GM-Tg-cynog-SE1441-Ab-1/ GM-Tg-cynog-SE1441-Ab-2Anti-Cynomolgus/ Rhesus macaque USP11 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1441-Ab-1/ GM-Tg-felg-SE1441-Ab-2Anti-Feline USP11 monoclonal antibodyFeline
GM-Tg-cang-SE1441-Ab-1/ GM-Tg-cang-SE1441-Ab-2Anti-Canine USP11 monoclonal antibodyCanine
GM-Tg-bovg-SE1441-Ab-1/ GM-Tg-bovg-SE1441-Ab-2Anti-Bovine USP11 monoclonal antibodyBovine
GM-Tg-equg-SE1441-Ab-1/ GM-Tg-equg-SE1441-Ab-2Anti-Equine USP11 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1441-Ab-1/ GM-Tg-hg-SE1441-Ab-2; GM-Tg-rg-SE1441-Ab-1/ GM-Tg-rg-SE1441-Ab-2;
GM-Tg-mg-SE1441-Ab-1/ GM-Tg-mg-SE1441-Ab-2; GM-Tg-cynog-SE1441-Ab-1/ GM-Tg-cynog-SE1441-Ab-2;
GM-Tg-felg-SE1441-Ab-1/ GM-Tg-felg-SE1441-Ab-2; GM-Tg-cang-SE1441-Ab-1/ GM-Tg-cang-SE1441-Ab-2;
GM-Tg-bovg-SE1441-Ab-1/ GM-Tg-bovg-SE1441-Ab-2; GM-Tg-equg-SE1441-Ab-1/ GM-Tg-equg-SE1441-Ab-2
Products NameAnti-USP11 monoclonal antibody
Formatmab
Target NameUSP11
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-USP11 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1441-Ag-1Recombinant multi-species UBP11/ USP11/ UHX1 protein


    Target information

    Target IDGM-SE1441
    Target NameUSP11
    Gene ID8237,236733,408217,706555,404014,101096382,538948,100051171
    Gene Symbol and Synonyms6230415D12Rik,mKIAA4085,UHX1,USP11
    Uniprot AccessionP51784,Q5D006,Q01988
    Uniprot Entry NameUBP11_HUMAN,UBP11_RAT,UBP11_CANLF
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000102226
    Target ClassificationN/A

    The target: USP11, gene name: USP11, also named as UHX1. Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This gene encodes a deubiquitinating enzyme which lies in a gene cluster on chromosome Xp11.23 [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.