Anti-DNS2A/ DNASE2/ DNASE2A functional antibody

Anti-DNS2A/ DNASE2/ DNASE2A functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to DNASE2/DNASE2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1449-Ab-1/ GM-Tg-hg-SE1449-Ab-2Anti-Human DNASE2 monoclonal antibodyHuman
GM-Tg-rg-SE1449-Ab-1/ GM-Tg-rg-SE1449-Ab-2Anti-Rat DNASE2 monoclonal antibodyRat
GM-Tg-mg-SE1449-Ab-1/ GM-Tg-mg-SE1449-Ab-2Anti-Mouse DNASE2 monoclonal antibodyMouse
GM-Tg-cynog-SE1449-Ab-1/ GM-Tg-cynog-SE1449-Ab-2Anti-Cynomolgus/ Rhesus macaque DNASE2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1449-Ab-1/ GM-Tg-felg-SE1449-Ab-2Anti-Feline DNASE2 monoclonal antibodyFeline
GM-Tg-cang-SE1449-Ab-1/ GM-Tg-cang-SE1449-Ab-2Anti-Canine DNASE2 monoclonal antibodyCanine
GM-Tg-bovg-SE1449-Ab-1/ GM-Tg-bovg-SE1449-Ab-2Anti-Bovine DNASE2 monoclonal antibodyBovine
GM-Tg-equg-SE1449-Ab-1/ GM-Tg-equg-SE1449-Ab-2Anti-Equine DNASE2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1449-Ab-1/ GM-Tg-hg-SE1449-Ab-2; GM-Tg-rg-SE1449-Ab-1/ GM-Tg-rg-SE1449-Ab-2;
GM-Tg-mg-SE1449-Ab-1/ GM-Tg-mg-SE1449-Ab-2; GM-Tg-cynog-SE1449-Ab-1/ GM-Tg-cynog-SE1449-Ab-2;
GM-Tg-felg-SE1449-Ab-1/ GM-Tg-felg-SE1449-Ab-2; GM-Tg-cang-SE1449-Ab-1/ GM-Tg-cang-SE1449-Ab-2;
GM-Tg-bovg-SE1449-Ab-1/ GM-Tg-bovg-SE1449-Ab-2; GM-Tg-equg-SE1449-Ab-1/ GM-Tg-equg-SE1449-Ab-2
Products NameAnti-DNASE2 monoclonal antibody
Formatmab
Target NameDNASE2
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-DNASE2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1449-Ag-1Recombinant multi-species DNS2A/ DNASE2/ DNASE2A protein


    Target information

    Target IDGM-SE1449
    Target NameDNASE2
    Gene ID1777,13423,171575,716802,476697,101086631,282218,100147278
    Gene Symbol and SynonymsAIPCS,DNASE2,DNASE2A,DNL,DNL2
    Uniprot AccessionO00115,Q9QZK8,P56541
    Uniprot Entry NameDNS2A_HUMAN,DNS2A_RAT,DNS2A_BOVIN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000105612
    Target ClassificationN/A

    The target: DNASE2, gene name: DNASE2, also named as DNASE2A, DNL, DNL2. This gene encodes a member of the DNase family. The protein, located in the lysosome, hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis. Two codominant alleles have been characterized, DNASE2*L (low activity) and DNASE2*H (high activity), that differ at one nucleotide in the promoter region. The DNASE2*H allele is represented in this record. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.