Anti-PAX4/ KPD/ MODY9 functional antibody

Anti-PAX4/ KPD/ MODY9 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to PAX4/PAX4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1451-Ab-1/ GM-Tg-hg-SE1451-Ab-2Anti-Human PAX4 monoclonal antibodyHuman
GM-Tg-rg-SE1451-Ab-1/ GM-Tg-rg-SE1451-Ab-2Anti-Rat PAX4 monoclonal antibodyRat
GM-Tg-mg-SE1451-Ab-1/ GM-Tg-mg-SE1451-Ab-2Anti-Mouse PAX4 monoclonal antibodyMouse
GM-Tg-cynog-SE1451-Ab-1/ GM-Tg-cynog-SE1451-Ab-2Anti-Cynomolgus/ Rhesus macaque PAX4 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1451-Ab-1/ GM-Tg-felg-SE1451-Ab-2Anti-Feline PAX4 monoclonal antibodyFeline
GM-Tg-cang-SE1451-Ab-1/ GM-Tg-cang-SE1451-Ab-2Anti-Canine PAX4 monoclonal antibodyCanine
GM-Tg-bovg-SE1451-Ab-1/ GM-Tg-bovg-SE1451-Ab-2Anti-Bovine PAX4 monoclonal antibodyBovine
GM-Tg-equg-SE1451-Ab-1/ GM-Tg-equg-SE1451-Ab-2Anti-Equine PAX4 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1451-Ab-1/ GM-Tg-hg-SE1451-Ab-2; GM-Tg-rg-SE1451-Ab-1/ GM-Tg-rg-SE1451-Ab-2;
GM-Tg-mg-SE1451-Ab-1/ GM-Tg-mg-SE1451-Ab-2; GM-Tg-cynog-SE1451-Ab-1/ GM-Tg-cynog-SE1451-Ab-2;
GM-Tg-felg-SE1451-Ab-1/ GM-Tg-felg-SE1451-Ab-2; GM-Tg-cang-SE1451-Ab-1/ GM-Tg-cang-SE1451-Ab-2;
GM-Tg-bovg-SE1451-Ab-1/ GM-Tg-bovg-SE1451-Ab-2; GM-Tg-equg-SE1451-Ab-1/ GM-Tg-equg-SE1451-Ab-2
Products NameAnti-PAX4 monoclonal antibody
Formatmab
Target NamePAX4
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-PAX4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1451-Ag-1Recombinant multi-species PAX4/ KPD/ MODY9 protein


    Target information

    Target IDGM-SE1451
    Target NamePAX4
    Gene ID5078,18506,83630,698351,482268,101099364,526172,100071708
    Gene Symbol and SynonymsKPD,MODY9,Pax-4,PAX4
    Uniprot AccessionO43316,O88436
    Uniprot Entry NamePAX4_HUMAN,PAX4_RAT
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000106331
    Target ClassificationN/A

    The target: PAX4, gene name: PAX4, also named as KPD, MODY9. This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The paired box 4 gene is involved in pancreatic islet development and mouse studies have demonstrated a role for this gene in differentiation of insulin-producing beta cells. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.