Anti-SIAE/ AIS6/ CSE-C functional antibody

Anti-SIAE/ AIS6/ CSE-C functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to SIAE/SIAE products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1458-Ab-1/ GM-Tg-hg-SE1458-Ab-2Anti-Human SIAE monoclonal antibodyHuman
GM-Tg-rg-SE1458-Ab-1/ GM-Tg-rg-SE1458-Ab-2Anti-Rat SIAE monoclonal antibodyRat
GM-Tg-mg-SE1458-Ab-1/ GM-Tg-mg-SE1458-Ab-2Anti-Mouse SIAE monoclonal antibodyMouse
GM-Tg-cynog-SE1458-Ab-1/ GM-Tg-cynog-SE1458-Ab-2Anti-Cynomolgus/ Rhesus macaque SIAE monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1458-Ab-1/ GM-Tg-felg-SE1458-Ab-2Anti-Feline SIAE monoclonal antibodyFeline
GM-Tg-cang-SE1458-Ab-1/ GM-Tg-cang-SE1458-Ab-2Anti-Canine SIAE monoclonal antibodyCanine
GM-Tg-bovg-SE1458-Ab-1/ GM-Tg-bovg-SE1458-Ab-2Anti-Bovine SIAE monoclonal antibodyBovine
GM-Tg-equg-SE1458-Ab-1/ GM-Tg-equg-SE1458-Ab-2Anti-Equine SIAE monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1458-Ab-1/ GM-Tg-hg-SE1458-Ab-2; GM-Tg-rg-SE1458-Ab-1/ GM-Tg-rg-SE1458-Ab-2;
GM-Tg-mg-SE1458-Ab-1/ GM-Tg-mg-SE1458-Ab-2; GM-Tg-cynog-SE1458-Ab-1/ GM-Tg-cynog-SE1458-Ab-2;
GM-Tg-felg-SE1458-Ab-1/ GM-Tg-felg-SE1458-Ab-2; GM-Tg-cang-SE1458-Ab-1/ GM-Tg-cang-SE1458-Ab-2;
GM-Tg-bovg-SE1458-Ab-1/ GM-Tg-bovg-SE1458-Ab-2; GM-Tg-equg-SE1458-Ab-1/ GM-Tg-equg-SE1458-Ab-2
Products NameAnti-SIAE monoclonal antibody
Formatmab
Target NameSIAE
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-SIAE benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1458-Ag-1Recombinant multi-species SIAE/ AIS6/ CSE-C protein


    Target information

    Target IDGM-SE1458
    Target NameSIAE
    Gene ID54414,22619,363045,711816,489311,101080322,507461,100072250
    Gene Symbol and SynonymsAIS6,CSE-C,CSEC,LSE,RGD1310431,SIAE,YSG2
    Uniprot AccessionQ9HAT2,P82450
    Uniprot Entry NameSIAE_HUMAN,SIAE_RAT
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000110013
    Target ClassificationN/A

    The target: SIAE, gene name: SIAE, also named as AIS6, CSE-C, CSEC, LSE, YSG2. This gene encodes an enzyme which removes 9-O-acetylation modifications from sialic acids. Mutations in this gene are associated with susceptibility to autoimmune disease 6. Multiple transcript variants encoding different isoforms, found either in the cytosol or in the lysosome, have been found for this gene.[provided by RefSeq, Feb 2011].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.